Membrane recognition by phospholipid-binding domains

By M. Lemmon. Nature reviews. Molecular cell biology, 2008

1,480 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f3eda084c1621040c676466d057331244531e4e0

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In Cell Biology

1. T. Balla
2. B. Vanhaesebroeck
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Citations in the corpus

• HELIQUEST: a web server to screen sequences with specific alpha-helical properties (2008, background): “This structural motif and its mode of membrane binding could appear simplistic, compared to well-structured domains (PH, PX, FYVE) that recognize specific lipids (Lemmon 2008).”
• Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication (2010, background): “…May 28, 2010 ª2010 Elsevier Inc. functions have recently emerged: several host proteins including CERT, OSBP, and FAPP1/2 specifically bind PI4P lipids (Lemmon, 2008); and PI4P lipids regulate selective autophagy and ER exit site biogenesis (Blumental-Perry et al., 2006; Yamashita et al., 2006).”
• A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival (2014, background): “7-9 Thus strict control of PtdIns(3,4,5)P3 levels in HSC is essential to prevent their conversion into leukemic stem cells (LSC).”
• The emerging mechanisms of isoform-specific PI3K signalling (2010, background): “PtdIns(3,4,5)P 3 and PtdIns(3,4)P 2 coordinate the localization and function of multiple effector proteins, which bind these lipids through their PH domai”
• SYMPOSIUM REVIEW: Phosphoinositides: lipid regulators of membrane proteins (2010, neutral): “1B), there also are PH domains that do not bind lipids at all (Lemmon, 2008).”
• Regulation of Phosphatidylinositol-5-Phosphate Signaling by Pin1 Determines Sensitivity to Oxidative Stress (2012, background): “In response to changes in the extracellular environment, intracellular environment, or both, these enzymes can establish subcellular profiles of phosphoinositides that interact with and regulate proteins containing specific lipid-binding domains to control cell proliferation, survival, and migration”
• Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer (2016, background): “Identification of the PS fatty acyl composition, its saturation, length, and oxidative status by mass spectrometry might be instructive in determining whether different externalization itineraries lead to discrete species of PS.”