Endosome maturation

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Brief update on endocytosis of nanomedicines (2019, methodology): “During the maturation process, morphological variations in the endosomes are coupled with a drop in pH [50].”
The lysosome: from waste bag to potential therapeutic target. (2013, background): “Trafficking between TGN and endosomes is a continuously ongoing process that is responsible for the removal of endosomal components and the delivery of lysosomal components (Huotari and Helenius, 2011).”
Endocytosis, Signaling, and Beyond (2014, background): “Endosome trafficking and fusion are regulated by a specific set of molecules, including but not limited to Rab GTPases and SNARE proteins (Brocker et al. 2010; Huotari and Helenius 2011; Jean and Kiger 2012).”
The delivery of therapeutic oligonucleotides (2016, background): “Subsequently there are two basic fates for materials that reach the early endosome; they can be shunted to lysosomes for degradation, or they can be recycled to the plasma membrane and cell exterior (128).”