Lysosomes: fusion and function

By J. Luzio, P. Pryor, N. Bright. Nature reviews. Molecular cell biology, 2007

1,694 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/984f829bcbe5f4107986bbf8c773eb19c21e5416

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Citations in the corpus

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids (2010, background): “the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids”
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function (2009, background): “In addition, endosomes can exchange content through vesicular transport carriers, tubular connections and kiss-and-run fusion event”
PI(3,5)P2 Controls Membrane Traffic by Direct Activation of Mucolipin Ca2+ Release Channels in the Endolysosome (2010, background): “For these general pathways, it has been postulated that Ca 2+ is released through unidentified Ca 2+ channels from the lumen of vesicles and organelle”
Pathogenic Lysosomal Depletion in Parkinson's Disease (2010, background): “Autophagy refers to the global process by which intracellular components are degraded by lysosomes, i.e., cytoplasmic membrane-enclosed organelles that contain a wide variety of hydrolytic enzymes and control the intracellular turnover of macromolecules (Luzio et al., 2007).”
Handbook of ion channels (2015, background): “This membrane fission process is also used by the membrane proteins that shuttle between LELs and TGN such as M6PR (61).”
Lysosomal membrane permeabilization and cell death (2018, background): “The delivery of lysosomal membrane proteins remains poorly understood, and is thought to be mediated indirectly via the plasma membrane or directly via an intracellular pathway.(8) Lysosomes can also be regenerated via a process called autophagic lysosome reformation (ALR).”
Liquid-liquid phase separation in biology. (2014, background): “Many compartments are separated by membranes, such as mitochondria, which contain a chemical environment necessary to make ATP (Friedman & Nunnari 2014), or lysosomes (Luzio et al. 2007), which contain components necessary to destroy other proteins.”
The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction. (2012, neutral): “In comparison to endosomes and autophagosomes, lysosomes are smaller in size, are highly enriched in particular transmembrane proteins and hydrolytic enzymes (including proteases, glycosidases, nucleases, phosphatases, and lipases), have a higher buoyant density, an electrondense appearance by trans”
Lysosomal Physiology (2015, background): “Although H+ flux and ψ may also indirectly affect lysosomal Ca2+ release (25), Ca2+ regulates most steps in lysosomal trafficking, including fusion of lysosomes with APs and late endosomes (LEs) (2, 26).”