The biogenesis of multivesicular endosomes

By J. Gruenberg, Harald A. Stenmark. Nature reviews. Molecular cell biology, 2004

772 citations recorded by the source corpus.

Recent progress has been made in our understanding of the molecular mechanisms that regulate the biogenesis of multivesicular transport intermediates in the degradation pathway that leads to lysosomes. Here, we discuss recent work that uncovers some of the mechanisms that cause both membrane invagination within these newly forming intermediates and the detachment of these intermediates from early endosomal membranes.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/8b81b3eee1f387b7194a900c3491778b2f2b82ea

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In Cell Biology

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In Molecular Biology

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In Physiology

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Citations in the corpus

• Notch signaling: the core pathway and its posttranslational regulation. (2009, background): “In mammalian cells, endocytosis of other activated receptors is often coupled to their monoubiquitination and recruitment into clathrin-rich endosomal membrane microdomains (Gruenberg and Stenmark, 2004).”
• Mycobacterium tuberculosis: Success through dormancy (2012, background): “This organelle is a part of the intracellular trafficking and transport system and the site to which the entire arsenal of host defense is targeted (Schekman, 1994; Rothman & Wieland, 1996; Gruenberg & Stenmark, 2004).”
• The tetraspanin CD63 regulates ESCRT-independent and dependent endosomal sorting during melanogenesis (2011, background): “machinery (Gruenberg and Stenmark, 2004; Hurley, 2008), in which the ESCRT-0, -I and II complexes recognize and sequester ubiquitinated proteins in the endosomal membrane and the ESCRT-III complex effects membrane budding and scission.”
• Exosomes: a common pathway for a specialized function. (2006, background): “C: Receiving lipids and proteins from the endocytic and the biosynthetic pathway, different subpopulations of MVBs may be generated whose composition confers them different fate: (1) back fusion of the ILVs with the limiting membrane.”
• Wnt Signaling Requires the Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes (2010, positive): “The key insight that led to the GSK3 sequestration hypothesis was the realization that during the normal endocytosis process, early endosomes containing activated receptors are packaged within multivesicular endosomes (McKanna et al., 1979; Katzmann et al., 2002; Gruenberg and Stenmark, 2004).”
• SNAREs and traffic. (2005, background): “Hrs interacts with SNAP-25 and functions in regulating the sorting event at the interface between early and late endosomes [126,127].”
• Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1 (2013, background): “Exosomes are released from multivesicular bodies (MVBs)(2) upon their fusion with the plasma membrane (13).”
• Membrane budding and scission by the ESCRT machinery: it's all in the neck (2010, neutral): “Multiple Snf7 molecules(57) polymerize downstream of Vps20 (2).”