The endocytic pathway: a mosaic of domains

By J. Gruenberg. Nature reviews. Molecular cell biology, 2001

762 citations recorded by the source corpus.

Organelles in the endocytic pathway are composed of a mosaic of structural and functional regions. These regions consist, at least in part, of specialized protein–lipid domains within the plane of the membrane, or of protein complexes associated with specific membrane lipids. Whereas some of these molecular assemblies can be found in more than one compartment, a given combination seems to be unique to each compartment, indicating that membrane organization might be modular.

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Citations in the corpus

Rapid endo‐lysosomal escape of poly(DL‐lactide‐coglycolide) nanoparticles: implications for drug and gene delivery (2002, background): “Similar sorting pathways at the level of early endosomes have been described for cell surface receptors that are either recycled back to the surface or degraded in the lysosomes (28).”
Dynamic Energy Budget Theory for Metabolic Organisation (2005, background): “No prokaryote seems to be able to wrap its membranes into vesicles, while membrane transport (including phagocytosis and pinocytosis, vesicle-mediated transport) is basic in eukaryotes [303, 437], and essential for endosymbiotic relationships.”
Distinct endocytic pathways regulate TGF-β receptor signalling and turnover (2003, background): “gif" NDATA ITEM> ]> In higher eukaryotic cells, internalization of plasma membrane proteins and lipids is mediated by clathrin-dependent and independent pathway”
The biogenesis of multivesicular endosomes (2004, background): “In fact, multivesicular elements of late endosomes contain a complex system of internal membranes that are involved in both the degradation and recycling of proteins and lipid”
Receptor downregulation and multivesicular-body sorting (2002, background): “Whereas early endosomes tend to be tubular and are located towards the cell periphery, late endosomes are more spherical and are often orientated closer to the nucleus (for reviews, see Ref”
The Arabidopsis GNOM ARF-GEF mediates endosomal recycling, auxin transport, and auxin-dependent plant growth. (2003, background): “In animals, distinct recycling other signaling events.pathways have been described (Gruenberg, 2001).”