Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

By Kazufumi Matsushita, O. Takeuchi, Daron M. Standley, Y. Kumagai, T. Kawagoe, Tohru Miyake, T. Satoh, H. Kato, T. Tsujimura, Haruki Nakamura and 1 more. Nature, 2009

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Regulation of cytoplasmic mRNA decay (2012, positive): “ZC3H12A (also known as MCPIP1) is the only example so far of an mRNA endonuclease that is transcriptionally induce”
Toll-Like Receptor Signaling Pathways (2014, background): “Regnase-1-deficient macrophages produce large amounts of cytokines after treatment with various TLR ligands, and Regnase1-deficient mice show elevated autoantibody production (78).”
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection (2010, background): “Jmjd3 has also been identified as an early TLR-inducible gene in mouse macrophages by microarray analysi”
IL-6 in inflammation, immunity, and disease. (2014, background): “…recently found that a nuclease known as regulatory RNase-1 (regnase-1) (also known as Zc3h12a) plays a part in the destabilization of IL-6 mRNA, and that the relevant knockout mice spontaneously develop autoimmune diseases accompanied by splenomegaly and lymphadenopathy (Matsushita et al. 2009).”
Transcriptional control of the inflammatory response (2009, background): “Finally, the endonuclease ZC3H12A was recently shown to regulate the stability of inducible gene transcript”
Pattern recognition receptors and inflammation. (2010, background): “RNase domain (Matsushita et al., 2009).”