Transcriptional control of the inflammatory response

By R. Medzhitov, T. Horng. Nature reviews. Immunology, 2009

1,046 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c78d5e08eeb5645ebc05527a4d06db94d6990fb4

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Citations in the corpus

FGF/FGFR signaling in health and disease (2020, background): “Inflammatory response is regulated by multiple factors in a variety of cellular behaviors.(525) Targeting pro-inflammatory factors such as IL-6 and TNF-α has been shown to be an effective therapy for some inflammatory diseases, and therapeutic antibodies are also promising strategy to treat inflamma”
The Role of the Transcription Factor CREB in Immune Function (2010, background): “Furthermore, CREB has been shown to induce transcription of immune-related genes that possess a CRE element, including IL-2, IL-6, IL-10, TNF-a, cyclooxygenase-2, and macrophage migration-inhibitory factor (2, 9, 10).”
Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription (2013, background): “…results in activation of several latent, signal-dependent transcription factors, including NF-kB, interferon regulatory factors (IRFs), AP-1 factors, and STAT factors, that act in a combinatorial manner to regulate the expression of thousands of genes (Medzhitov and Horng, 2009; Smale, 2012).”
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses (2011, background): “1, C/EBPβ, Runx1 and IRF8, which are lineage-specific transcriptional regulators turned on during macrophage differentiatio”
NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration (2019, background): “NF-κB signaling is crucial for a multitude of important immunological transcriptional programs, including inflammatory responses to microbes and viruses by innate immune cells (2, 5, 6), development and activation of adaptive immune cells (7, 8), as well as the development of secondary lymphoid orga”
The role of oxidative stress during inflammatory processes (2013, background): “Such signaling cascades foster the expression of cytokines, chemokines, enzymes, growth factors, and additional molecules that are required for antimicrobial resistance and tissue repair (Medzhitov and Horng, 2009; Tang et al., 2012b).”
Angiotensin II revisited: new roles in inflammation, immunology and aging (2010, background): “Inflammation involves activation of the endothelium of blood vessels and expression of diverse endothelial cell selectins that dictate extravasation of specific leukocyte populations to the site of injury (Medzhitov & Horng, 2009; Pober & Sessa, 2007).”
Discovery of cell-type specific DNA motif grammar in cis-regulatory elements using random Forest (2018, background): “The binding of different TFs to DNA is critical for the regulation of gene expression in almost all important biological processes, including embryogenesis [2–4], cell cycle and development control [5–7], and response to intercellular signals and environment [8, 9].”
Transition from inflammation to proliferation: a critical step during wound healing (2016, background): “, H2AK119 ubiquitylation and H3K27 trimethylation inhibit the expression of TLR-signal-targeted genes [127].”
Immunity, inflammation, and cancer: an eternal fight between good and evil. (2015, neutral): “Both PAMPs and DAMPs are recognized by pattern-recognition receptors (PRRs), many of which belong to the TLR family (5, 6).”
Latent enhancers activated by stimulation in differentiated cells. (2013, neutral): “Macrophages are equipped with a plethora of receptors allowing them to sense, and react to, a broad panel of agonists (Medzhitov and Horng, 2009).”