Regulation of cytoplasmic mRNA decay

By Daniel R Schoenberg, L. Maquat. Nature reviews genetics, 2012

694 citations recorded by the source corpus.

Discoveries made over the past 20 years highlight the importance of mRNA decay as a means of modulating gene expression and thereby protein production. Up until recently, studies largely focused on identifying cis-acting sequences that serve as mRNA stability or instability elements, the proteins that bind these elements, how the process of translation influences mRNA decay and the ribonucleases that catalyse decay. Now, current studies have begun to elucidate how the decay process is regulated. This Review examines our current understanding of how mammalian cell mRNA decay is controlled by different signalling pathways and lays out a framework for future research.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3319b297c4abcc999558f8596485bbc8fd7714df

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Citations in the corpus

• Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation (2017, positive): “…our model that mRNA decay regulates neuronal lineage gene expression in RGCs, we performed in vivo knockdown experiments for the components of CCR4-NOT complex (Cnot7 and Cnot1), a major cytoplasmic mRNA deadenylase complex responsible for mRNA decay (Du et al., 2016; Schoenberg and Maquat, 2012).”