The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

By T. Satoh, O. Takeuchi, A. Vandenbon, K. Yasuda, Yoshiaki Tanaka, Y. Kumagai, Tohru Miyake, Kazufumi Matsushita, T. Okazaki, T. Saitoh and 8 more. Nature Immunology, 2010

1,139 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Parasitology

View Paper: https://www.semanticscholar.org/paper/661da9ea5cd048c1de8014cae6cfdf02f5eea476

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Citations in the corpus

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses (2011, background): “Subsequent evidence has suggested that in mice, IRF4 controls M2 macrophage polarization by stimulating the expression of specific M2 macrophage marker”
INTERLEUKIN-4- AND INTERLEUKIN-13-MEDIATED ALTERNATIVELY ACTIVATED MACROPHAGES: ROLES IN HOMEOSTASIS AND DISEASE (2013, neutral): “Nevertheless, the additional demonstration that the gene encoding the transcription factor interferon regulatory factor 4 (Irf4) is the Jmjd3 target gene responsible for controlling AAM marker expression (31) is of potential relevance in light of other recent studies showing that, in contrast to AAM”
Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. (2016, background): “Additionally, interferon regulatory factor (IRF)-4, a key transcription factor controlling M2 polarization (Satoh et al., 2010), also exhibited neuroprotective effects in ischemic stroke (Guo et al.”
Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils (2011, background): “In addition to IL-4 and IL-13, IL-10, IL-21, the cell-signaling molecule GM-CSF, IL-33 and unique transcription factors regulate the differentiation of M2 cell”
Transcriptional regulation of macrophage polarization: enabling diversity with identity (2011, background): “, or for functional specialization, such as IRF4 and IRF5 (which are involved in M2 and M1 polarization, respectively) and CCAAT/enhancer-binding protein-β (C/EBPβ”
Microglia in the TBI Brain: The Good, The Bad, And The Dysregulated (2015, background): “For example, IL-4 induces the upregulation of the histone demethylase Jmjd3 in macrophages, which alters chromatinmodifications to promoteM2 gene expression and inhibition of M1 genes (Ishii et al., 2009; Satoh et al., 2010).”
Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria (2017, result): “Similar to what we observed after SP140 knockdown, genetic deletion or chemical inhibition of JMJD3 resulted in significantly altered macrophage activation after exposure to helminth or bacteria (53, 54).”
Krüppel-like factor 4 regulates macrophage polarization. (2011, background): “Finally, while much of our work here has focused on M2 polarization in the context of IL-4 stimulation, a recent study suggested that alternative IL-4–independent mechanisms may also regulate the M2 phenotype (45).”
Coordinated regulation of myeloid cells by tumours (2012, background): “However, the genetic ablation of Jmjd3 in mice causes a defect in interferon-regulatory factor 4 (IRF4)-dependent M2 polarization in response to M-CSF, helminth infection or chitin administration, but not following IL-4 stimulation, suggesting a more complex regulatory networ”
Macrophage plasticity and polarization: in vivo veritas. (2012, neutral): “Epigenetic changes and noncoding RNAs also participate in directing macrophage polarization (32–34).”
Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages (2015, methodology): “IRF4, a member of IRF family, is involved in M2 polarization and functions as a negative regulator of TLR signaling by association with the MyD88 adaptor molecule (102).”