IL-6 in inflammation, immunity, and disease.

By Toshio Tanaka, M. Narazaki, T. Kishimoto. Cold Spring Harbor Perspectives in Biology, 2014

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Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “Furthermore, the release of IL-6 from pyroptotic cells contributes to the adaptive response by increasing cell trafficking, differentiation, and antibody production of CD8+ T cells, inhibiting Tregs differentiation and macrophages death.(221,222) Interestingly, it is increasingly recognized that mem”
Gut Microbiota-Targeted Diets Modulate Human Immune Status (2020, positive): “elevated in several chronic inflammatory conditions such as rheumatoid arthritis, type-2 diabetes, and chronic stress, and is a commonly used metric of inflammation (reviewed in (Tanaka et al., 2014)).”
Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies (2020, background): “Except for STAT1, STAT3, and STAT5 in the splenocytes of SLE-prone MRL/lpr mice could be inhibited by SM934, an artemisinin derivative (122).”
The Gut Microbiota and Inflammation: An Overview (2020, background): “* Contrasting mechanisms demonstrate that this cytokine is both involved in pro- and anti-inflammatory processes [101,103].”