Pattern recognition receptors and inflammation.

By O. Takeuchi, Shizuo Akira. Cell, 2010

8,506 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/219e2d53849b7dde97def6c0eda47d31e025dc5a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. Zhijian J. Chen
3. Taro Kawai
4. O. Takeuchi
5. Himanshu Kumar
6. R. Medzhitov
7. G. Barber
8. Lijun Sun

In Molecular Biology

1. Shizuo Akira
2. M. Lamkanfi
3. Zhijian J. Chen
4. Taro Kawai
5. V. Dixit
6. G. Núñez
7. Yuan He
8. O. Takeuchi

Citations in the corpus

• Biology and Diseases of Mice (2015, neutral): “Receptors include the Toll-like receptors (TLRs), such as TLR4 (recognizing LPS), TLR3/7 (ss and dsRNA) and TLR9 (DNA), NOD-like receptors (NOD1/2), and RIG-like receptors (RIG-I, MDA-5) among others (Takeuchi and Akira, 2010) .”
• Signaling in innate immunity and inflammation. (2012, background): “Differences have been noted in myeloid DCs(1); IRF1 is more important than IRF7, and there does not seem to be a requirement for TRAF3 and IRAK1 (Hoshino et al. 2010; Takeuchi and Akira 2010).”
• Regulation of ligands for the NKG2D activating receptor (2013, background): “Among the innate signaling pathways are those triggered by Toll-like receptors (TLRs) and intracellular sensors of microbial molecules such as NOD-like receptors (NLRs), RNA sensors, DNA sensors, and sensors of microbe-derived cyclic dinucleotides (45).”
• Cytosolic Sensing of Viruses (2013, background): “Several cytosolic molecules that are also involved in other innate signaling responses are subsequently recruited to MAVS prions (Takeuchi and Akira, 2010).”
• Sterile inflammation: sensing and reacting to damage (2010, background): “There are several classes of receptors that are important for sensing microorganisms and for the subsequent induction of pro-inflammatory responses (for a review, see Ref”
• The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation (2019, background): “The innate immune system is the first line of host defense and the engagement of germline-encoded pattern-recognition receptors (PRRs) activate it in response to harmful stimuli, such as invading pathogens, dead cells, or environmental irritants [1].”
• Vaccine Adjuvants: Putting Innate Immunity to Work (2010, background): “…such as peptidoglycan species, flagellin, toxins, and ATP; helicases (RIG-I-like receptors, RLR) triggered by cytoplasmic RNA; and C-type lectin receptors (CLRs) recognizing carbohydrates and lipids (Beutler, 2009; Iwasaki and Medzhitov, 2010; Kawai and Akira, 2010; Takeuchi and Akira, 2010).”