The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase

By S. Cullinan, John D. Gordan, Jianping Jin, J. Harper, J. Alan Diehl. Molecular and Cellular Biology, 2004

968 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/8391360d24683e77132d9ba0c8b9087f1ef0ffbb

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Citations in the corpus

Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1 (2006, background): “It has been shown previously that Keap1 binds to Nrf2 and represses its activity (15, 16, 18) and that Keap1 promotes the rapid turnover of Nrf2 through the ubiquitin-proteasome pathway utilizing Cul3based E3 ligase (6, 11, 22, 44).”
SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner (2011, background): “of Nrf2 protein in a redox-dependent fashion (5, 20, 51).”
Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway (2006, background): “…from our laboratory and others indicate that Keap1 does not just passively sequester Nrf2 in the cytoplasm but plays an active role in targeting Nrf2 for ubiquitination and proteasomal degradation (Cullinan et al., 2004; Kobayashi et al., 2004; Zhang et al., 2004; Furukawa and Xiong, 2005).”
Sequence and structural analysis of BTB domain proteins (2005, background): “In contrast to the BTB-ZF proteins, but similar to the BBK proteins, MATH-BTB sequences are highly conserved across the full lengths of the proteins.”
The emerging role of the Nrf2–Keap1 signaling pathway in cancer (2013, background): “…with Keap1, which is a substrate adaptor protein for the Cullin 3 (Cul3)dependent E3 ubiquitin ligase complex that represses Nrf2 by promoting its ubiquitination and subsequent proteasomal degradation (Cullinan et al. 2004; Kobayashi et al. 2004; Zhang et al. 2004; Furukawa and Xiong 2005).”
Transcriptional Regulation by Nrf2 (2017, background): “Keap1 functions as an adaptor protein for the Cul3 E3 ubiquitin ligase, which is responsible for the continuous ubiquitylation and degradation of Nrf2 (28, 37, 80, 192).”
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. (2006, background): “Recent studies suggest that Keap1 recruits cullin3, a subunit of the E3 ligase complex to Nrf2, to promote its ubiquitination (128, 332, 775).”
Molecular Mechanisms of Nrf2-Mediated Antioxidant Response (2009, background): “The BTB domain [36-39] and probably part of the IVR domain [39] bind to the ubiquitination catalytic complex.”
Expression of Nrf2 in Neurodegenerative Diseases (2007, positive): “It has been reported that cytoplasmic Nrf2 interacts with the Keap1:Cul3 complex, an ubiquitin E3 ligase complex that leads to Nrf2 degradation by the proteasome (15).”
The cytoprotective role of the Keap1–Nrf2 pathway (2011, background): “Four groups independently reported that Keap1 was able to bind to Cul3 and ubiquitinate Nrf2 both in vivo and in vitro (Kobayashi et al. 2004; Cullinan et al. 2004; Zhang et al. 2004; Furukawa and Xiong 2005).”