Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

By K. Orford, D. Scadden. Nature reviews genetics, 2008

915 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/7f76d99251096c519ce799c251bcb655aedeed70

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. P. Bonaldo
2. Aviv Regev
3. R. Weinberg
4. F. Gattazzo
5. A. Urciuolo
6. Anne Wilson
7. A. Trumpp

In Molecular Biology

1. R. Weinberg
2. José C. R. Silva
3. Jesús Gil
4. P. Bonaldo
5. Aviv Regev
6. Suzanne J. Baker
7. L. Vallier
8. F. Gattazzo

In Oncology

1. R. Weinberg
2. Jesús Gil
3. P. Bonaldo
4. L. Vallier
5. F. Gattazzo
6. A. Urciuolo
7. M. Nieto
8. D. Hanahan

Citations in the corpus

• An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors (2008, background): “As ES cells are characterized by a high proliferation rat”
• Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “maintains stem cells in a quiescent and low metabolic state to prevent stem cell exhaustion [22].”
• Arteriolar niches maintain haematopoietic stem cell quiescence (2013, neutral): “In the bone marrow (BM), recent studies have highlighted the critical influence of the microenvironment in regulating haematopoietic stem cell (HSC) maintenance 4 .”
• Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. (2009, positive): “Although it is generally assumed that most immature adult stem cells divide infrequently and are predominantly quiescent (Arai and Suda, 2007; Orford and Scadden, 2008 ), recent reports raise the possibility that dormancy is either not a typical feature of somatic stem cells or that it may depend o”
• Insulin signaling promotes germline proliferation in C. elegans (2010, background): “Although major cell cycle regulators are defined, less is known about the control of cell proliferation by growth factors within developmental contexts (e.g. Edgar and Lehner, 1996; Fichelson et al., 2005; Orford and Scadden, 2008).”
• The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance (2011, background): “Although HSC quiescence has been proposed to play protective functions against stem cell exhaustion and against the acquisition of mutations leading to malignant transformation (Lobo et al., 2007; Orford and Scadden, 2008), the role of autophagy in these processes remains unknown.”
• Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “Consequently a short G1 in mouse ES cells allows them to avoid the differentiation-inducing signals mediated by certain mitogenic signalling pathways that are usually active during early G1 in somatic cells (Orford and Scadden, 2008).”
• Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis (2010, background): “In terms of organ maintenance, it is logical to keep long-lived HSCs quiescent in vivo to guard them against DNA replication errors and damage associated with oxidative stress (Rossi et al., 2007; Orford and Scadden, 2008).”
• Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis (2010, background): “We do not yet know whether this depletion of NSCs is due to their premature differentiation or their exhaustion resulting from increased proliferation [46].”