The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

By Monika Mortensen, E. Soilleux, G. Djordjević, Rebecca Tripp, Michael Lutteropp, E. Sadighi-Akha, A. Stranks, S. Knight, S. W. W. Jacobsen, Kamil R. Kranc and 1 more. Journal of Experimental Medicine, 2011

641 citations recorded by the source corpus.

Adult mouse LSK cells unable to undergo autophagy contain fewer HSCs, accumulate mitochondria, and fail to reconstitute lethally irradiated mice.

Subfields: Epidemiology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3bed215b5b6e9972cc4fa096d662e3387bbd4c2e

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In Epidemiology

1. Guido Kroemer
2. Beth Levine
3. L. Galluzzi
4. Alec C. Kimmelman
5. Guillermo Mariño
6. P. Codogno
7. D. Rubinsztein
8. N. Mizushima

In Genetics

1. G. Semenza
2. Guido Kroemer
3. T. Suda
4. Beth Levine
5. K. Takubo
6. C. V. Dang
7. Navdeep S. Chandel

In Molecular Biology

1. Guido Kroemer
2. Beth Levine
3. L. Galluzzi
4. Guillermo Mariño
5. D. Rubinsztein
6. Eric H. Baehrecke
7. F. Pietrocola
8. P. Codogno

Citations in the corpus

• Autophagy and aging. (2011, background): “Though other mTOR-related functions may contribute, at least part of this phenotype may be mediated by deficient autophagy because atg7 knockout leads to a severe attrition of the hematopoietic stem cell and progenitor cell compartments (Mortensen et al., 2011).”
• Autophagy in malignant transformation and cancer progression (2015, positive): “The ablation of Atg7 in murine hematopoietic stem cells (HSCs) has been shown to disrupt tissue architecture, eventually resulting in the expansion of a population of bone marrow progenitor cells with neoplastic features (Mortensen et al , 2011).”
• Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011, background): “Atg7-deficient LSK cells also fail to reconstitute the hematopoietic system of lethally irradiated mice (Mortensen et al., 2011).”
• Evolution of the immune system in humans from infancy to old age (2015, positive): “Mice without autophagy in their haematopoietic system display a prematurely aged haematopoietic system [106].”