Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis

By Alfonso J. Lavado, O. Lagutin, L. Chow, Suzanne J. Baker, G. Oliver. 2010

233 citations recorded by the source corpus.

The transcription factor Prox1 plays a crucial role in intermediate progenitor maintenance and hippocampal neuron differentiation during adult neurogenesis in the dentate gyrus region of the hippocampus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

In Molecular Biology

Citations in the corpus

Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement (2014, background): “…Transcription factor DG Quadrato et al., 2012 NF-KappaB p50 Transcription factor DG Denis-Donini et al., 2008 CREB Transcription factor DG Jagasia et al., 2009 Neuro D1 Transcription factor DG, SVZ Gao et al., 2009 PROX1 Transcription factor DG Lavado et al., 2010; Karalay et al., 2011”
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “In contrast, Prox1 (Lavado et al., 2010), NeuroD (Gao et al.”
Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells (2014, background): “The sustained presence of PROX1 is necessary to specify the granule neuron identity relative to the CA3 pyramidal fate in the hippocampus, and the loss of Prox1 in immature DG neurons results in the manifestation of CA3 pyramidal neuronal properties (Lavado et al., 2010; Iwano et al., 2012).”
The germinal matrices in the developing dentate gyrus are composed of neuronal progenitors at distinct differentiation stages (2013, methodology): “, 2013), and its genetic disruption abolishes DG (Lavado et al., 2010), we used Prox1 as a reliable postmitotic”
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, unknown): “While Prox1 ablation increased cell death of late-stage precursors (Lavado et al., 2010), NeuroD1 appeared to be crucial for the survival of maturing dentate granule neurons (Gao et al.”
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis (2011, background): “However, this may change in a situation in which Prox1 is chronically depleted: Lavado and colleagues found defective maintenance of radial glia-like NSCs 2 mo after Prox1 KO (17).”