Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.

By Anne Wilson, E. Laurenti, G. Oser, R. C. van der Wath, W. Blanco-Bose, Maike Jaworski, Sandra Offner, Cyrille F. Dunant, L. Eshkind, E. Bockamp and 3 more. Cell, 2009

1,936 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Oncology

View Paper: https://www.semanticscholar.org/paper/fc69bbb77dc6eb6e2eac27a37fbe2c749218cb32

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. G. Semenza
2. P. Frenette
3. T. Suda
4. Aviv Bergman
5. Steffen Jung
6. Amos Tanay
7. K. Takubo
8. S. Morrison

In Hematology

1. S. Morrison
2. G. Semenza
3. P. Frenette
4. Sandra Pinho
5. T. Suda
6. Steffen Jung
7. K. Takubo
8. E. Laurenti

In Oncology

1. T. Suda
2. A. Mildner
3. Steffen Jung
4. K. Takubo
5. S. Morrison
6. Shenghui He
7. G. Semenza
8. P. Vaupel

Citations in the corpus

• Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. (2015, background): “…al., 2005; Arinobu et al., 2007; Bendall et al., 2014; Görgens et al., 2013; Levine et al., 2015; Murre, 2007; Pronk et al., 2007; Schroeder, 2010; Wilson et al., 2008; Yamamoto et al., 2013), it has become difficult to follow up functional evidence with continuous refinement of the tree model…”
• The aged niche disrupts muscle stem cell quiescence (2012, methodology): “To further define the loss of quiescence after elevated FGF signalling under homeostasis, we assessed BrdU label retention character (BrdU-LRC), a readout of slow dividing stem cell behavior 36 in adult and aged Spry1null and control mice (Fig.”
• Mechanisms of stem cell self-renewal. (2009, background): “…self-renewal upon serial transplantation in irradiated mice; however, under physiological conditions in vivo, most HSCs are quiescent most of the time and may undergo a limited number of self-renewing divisions in normal adult mice (Cheshier et al. 1999, Foudi et al. 2008, Wilson et al. 2008).”
• Arteriolar niches maintain haematopoietic stem cell quiescence (2013, positive): “Cell cycle analysis was performed as previously described 10 .”
• A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation. (2016, methodology): “Each cell was also stained with 3 additional antibodies against CD150,CD48, andEPCR to retrospectively assign cells to other commonly used sorting schemes for populations such as E-SLAM(3) or MPP subpopulations.(27,29) Single cells were processed for RNA-Seq as described(21) with 156 HSCs, 701 HSPCs”