Unexpected complexity of the Wnt gene family in a sea anemone

By Arne Kusserow, K. Pang, Carsten Sturm, Martina Hrouda, Jan Lentfer, Heiko A. Schmidt, U. Technau, A. von Haeseler, B. Hobmayer, M. Martindale and 1 more. Nature, 2005

618 citations recorded by the source corpus.

Subfields: Global and Planetary Change, Molecular Biology, Paleontology

View Paper: https://www.semanticscholar.org/paper/7e9fcb05458c57b86ed8a841f431aa109a5baea4

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Citations in the corpus

Towards an integrated view of Wnt signaling in development (2009, background): “Orthologs are grouped together based on published phylogenetic analyses (Huang and Klein, 2004; Kusserow et al., 2005; Lengfeld et al., 2009; Minobe et al., 2000; Momose and Houliston, 2007; Prud’homme et al., 2002; Schubert et al., 2000).”
Evo‐Devo and an Expanding Evolutionary Synthesis (2008, neutral): “These include numerous instances of fur and plumage changes associated with evolution of the Melanocortin-1 receptor (MC1R; see Mundy, 2005 for review); the independent evolution of albinism in different cave fish populations due to coding mutations in the Oca2 gene (Protas et al., 2006); and differ”
The many faces and functions of β‐catenin (2012, neutral): “…14 Wnt genes have been identiﬁed which belong to 12 of the 13 known different Wnt subfamilies, 11 of which are also present in vertebrates, where some additional duplication events within individual subfamilies lead to expression of up to 19 different Wnts in mammals (Kusserow et al , 2005).”
Higher-level metazoan relationships: recent progress and remaining questions (2011, background): “It has been shown that ‘simple’ animals such as the sea anemone Nematostella vectensis have the complete set of bilaterian WNT genes (Kusserow et al. 2005) and that the complex segmented arthropod legs follow the same patterning system as the non-articulated legs of onychophorans (Janssen et al.”
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities (2022, background): “Wnts are secreted proteins, and 19 Wnt proteins have been identified in the human body.(10) Among them, Wnt3a and Wnt1 act as ligands to activate the Wnt/β-catenin signalling pathway after translation and modification.”
Evolution by gene loss (2016, background): “Finally, comparison of gene loss catalogues between organisms that have suffered convergent processes of regressive evolution in structures or biological processes related to a human disease will help in discerning new candidate genes for diseases (6), as has already been demonstrated for the BBS5 g”
Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “A recent example is Notum, originally discovered in Drosophila as an enzyme, a carboxylesterase that can remove the palmitoleate modification on Wnt (Kakugawa et al., 2015; Zhang et al., 2015) (Figure 1).”
Structural basis of WLS/Evi-mediated Wnt transport and secretion (2020, background): “The multiple roles that Wnt family members play in body plan development and homeostasis across all animal species is highlighted by the diverse number of conserved paralogs present in different organisms: for example, the human and mouse genomes have 19 Wnt genes, while the sea anemone Nematostella”
Evolution at Two Levels: On Genes and Form (2005, background): “Of 12 Wnt subfamilies known in vertebrates, 11 have been identified in a cnidarian [57].”
Wnt/beta-catenin signaling in development and disease. (2006, positive): “Thus, comparative genomic analysis underscores the crucial role that Wnt genes play in organismal patterning throughout the animal kingdom (Kusserow et al., 2005).”
Wnt/β-catenin signaling and disease. (2012, positive): “At least 11 of these subfamilies occur in the genome of a Cnidaria (the sea anemone Nematostella vectensis), emphasizing the crucial role that Wnt proteins play in organismal patterning throughout the animal kingdom (Kusserow et al., 2005).”