The many faces and functions of β‐catenin

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Osteoarthritis: pathogenic signaling pathways and therapeutic targets (2023, background): “β-catenin is a subunit of the cadherin protein complex and the co-activator to promote its downstream target gene transcription.(137) In the cytoplasm, β-catenin binds to cadherin protein on the cell membrane attaching to cytoskeleton protein actin and participating in cell adhesion.”
Wnt/β-catenin signaling in cancers and targeted therapies (2021, background): “Finally, after receiving the upstream activation signals, β-catenin functions as the ultimate effector.(31,32) Without canonical Wnt ligands, β-catenin binds to cadherin of cytoplasmic sides rather than being transported into the nucleus, further phosphorylated and eliminated by degradation complex.”
Transcriptomic profile induced by calcitriol in CaSki human cervical cancer cell line (2025, unknown): “These proteins exhibit common traits including transcriptional regulation, participation in cellular proliferation and differentiation, and involvement in protein-protein regulatory networks [72–74].”