Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

By Jiaqi Liu, Qing Xiao, Jian-Ying Xiao, Chenxi Niu, Yuanyuan Li, Xiaojun Zhang, Zhengwei Zhou, Guang Shu, Gang Yin. Signal Transduction and Targeted Therapy, 2022

2,114 citations recorded by the source corpus.

The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/10bedf416db381234f510a6bec173655b4b1b9c4

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1. Mingxi Lin
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5. Qing Guo
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8. Xinyu Chen

Citations in the corpus

• NF-κB in biology and targeted therapy: new insights and translational implications (2024, background): “151,152 In contrast, it has been revealed that Dvl interacts with p65 in the nucleus and inhibits NF-κ B-mediated transcriptional activation, and promotes apoptosis, independently of Wnt or β -catenin.”