Evolution at Two Levels: On Genes and Form

By Sean B. Carroll. PLoS Biology, 2005

846 citations recorded by the source corpus.

Emerging knowledge about organismal evolution suggests that changes in the regulation of gene expression have played a major role - a thesis proposed 30 years ago by King and Wilson.

Subfields: Astronomy and Astrophysics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/50375c4b8aa2ac7846b680172deaf010cd0b0fa6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Astronomy and Astrophysics

In Molecular Biology

Citations in the corpus

Functional and Evolutionary Insights Into Human Brain Development Through Global Transcriptome Analysis (2009, background): “icantly to the evolution of human brain uniqueness (King and Wilson, 1975; Carroll, 2005; Khaitovich et al., 2006; Sikela, 2006; Vallender et al., 2008; Varki et al., 2008).”
Genetics, development and evolution of adaptive pigmentation in vertebrates (2006, background): “More recently, mutations in regulatory regions have been proposed as a mechanism to fine-tune phenotypes because mutations in specific cis-regulatory elements may alter the expression of a protein in particular tissues, while preserving expression in others (Stern, 2000; Carroll et al, 2001; Carroll”
The roles of membrane transporters in arsenic uptake, translocation and detoxification in plants (2020, background): “Transcriptional regulation is an early event during gene expression, which is largely controlled by transcription factors (Carroll, 2005; Castrillo et al., 2011).”
Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data (2011, neutral): “This hypothesis is further supported by an abundance of heritable factors altering gene expression 56 that are enriched within trait-associated loci 57 and the observation that regulatory variation is a major driver of morphological differences between closely related species 58,59 .”
Divergence of duplicate genes in exon–intron structure (2012, background): “, morphogenes) tend to accumulate more changes in regulatory regions (27, 31, 32).”
Molecular mechanisms of heavy metal tolerance and evolution in invertebrates (2009, background): “Since the emergence of the multi-disciplinary science of evolutionary and ecological functional genomics (EEFG) (Feder & Mitchell-Olds, 2003), a lively debate has been going on addressing the question whether adaptive nucleotide polymorphisms are mainly due to mutations affecting the structure of pr”
The Loci of Evolution: How Predictable is Genetic Evolution? (2008, background): “Occasionally, the idea that physiological evolution might involve more coding changes than morphological evolution has been made explicit (Carroll 2005).”
Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium (2009, background): “This divergence seems to arise through the gain and loss of regulatory binding sites from the promoters during evolution, in a manner that is analogous to the evolution of many developmental differences in genera of higher organism”
Evo‐Devo and an Expanding Evolutionary Synthesis (2008, background): “Stern (2000) and I (Carroll, 2005) have argued that the most important determinant of what kinds of mutations are permissible under natural selection is the potential pleiotropic effects of individual mutations.”
The Role of PHT1 Family Transporters in the Acquisition and Redistribution of Phosphorus in Plants (2019, background): “Under LPC, the transcription of PHT1 genes is controlled by transcription factors (TFs) binding to cis-elements located in the promoter region of PSR or AMF inducible PHT1 genes (Carroll, 2005; Castrillo et al., 2011).”
Hybrid error correction and de novo assembly of single-molecule sequencing reads (2012, background): “One striking example is the language and song–associated FOXP2 gene 29–34 , which is highly fractured in all but the PBcR assemblies ( Supplementary Fig.”
DNA transposons and the evolution of eukaryotic genomes. (2007, background): “The generation of new alleles and the creation of novel regulatory circuits are major forces underlying the diversification of species (14, 24, 104, 196).”