Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities
By R. Nusse, Hans Clevers. 2017
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- Qing Guo
- Hui-Ying Zhao
- Yizi Jin
- Z. Steinhart
- Tianqi Ming
- Xinyu Chen
- Shunlei Tang
- Shan Ren
Citations in the corpus
- Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity (2023, background): “Wnt signalling plays a key role in embryonic development and adult biology, and has become a drug target of considerable interest for human disease [3].”
- Osteoarthritis: pathogenic signaling pathways and therapeutic targets (2023, background): “The reduction of solubility of Wnt ligands strongly limits their physical signaling transduction capacity in different tissues and typically generates concentration gradients impacting adjacent cell behavior.(134,135) With both paracrine and autocrine effects, Wnt signaling was demonstrated to play ”
- Wnt signaling in colorectal cancer: pathogenic role and therapeutic target (2022, background): “Current research on the Wnt pathway is mostly focused on the Wnt pathway On the Wnt/β-catenin branch, dysregulation of this pathway is related to many diseases [6] (Fig.”
- Cuproptosis: mechanisms and links with cancers (2023, background): “The Wnt signaling pathway maintains the renewal balance of human cells, and activation of whose genes exerts a protumor effect in tumor cells [65].”
- Wnt/β-catenin signaling in cancers and targeted therapies (2021, background): “Wnt/β-catenin and Sonic hedgehog (Shh) signaling The Sonic hedgehog signaling is another important interactor of β-catenin-dependent Wnt signaling.(9,264) Smo, a receptor of Shh ligands,(265) once being triggered via Shh, can activate Gli activities.”
- Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities (2022, background): “Wnt/β-catenin signalling is essential to maintain the undifferentiated state of the stem cell population in the intestinal epithelium Abnormal activation of the Wnt/β-catenin pathway by mutations in adenomatous polyposis coli, AXIN2, or β-catenin (CTNNB1) is responsible for the initiation of almost ”
- Structural model of PORCN illuminates disease-associated variants and drug binding sites (2021, unknown): “Wnt ligand binding to receptors and coreceptors on the surface of target cells initiates an array of downstream signaling events, most notably β-catenin mediated transcription (Jung and Park, 2020; Nusse and Clevers, 2017; Yu and Virshup, 2014).”