Towards an integrated view of Wnt signaling in development
By Renée van Amerongen, R. Nusse. Development, 2009
1,219 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/182f50651ee688169031b9c0c628d27b913a98fb
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Hans Clevers
- R. Nusse
- G. Schulte
- J. Petersen
- J. Dijksterhuis
- C. Bentzinger
- Yu Xin Wang
- Casey S. Greene
Citations in the corpus
- Understanding multicellular function and disease with human tissue-specific networks (2015, positive): “We focused on the transcription factor LEF1 that plays a key role in mediating the tissue-specific response to Wnt signaling 28 , a fundamental and highly conserved pathway known to elicit diverse cell-type-specific developmental responses 29 .”
- An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014, background): “In some instances, Wnt signals are transduced independently of b-catenin—for example, during morphogenetic movements in vertebrate gastrulation (8).”
- INTERNATIONAL UNION OF BASIC AND CLINICAL PHARMACOLOGY REVIEW WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3 (2014, positive): “The role of FZDs in many types of cancer and other diseases is diverse, rendering class FZD receptors an obvious target for therapeutic intervention (Logan and Nusse, 2004; Janssens et al., 2006; van Amerongen and Nusse, 2009; Chien et al., 2009; King et al., 2012).”
- Wnt/beta-catenin pathway: modulating anticancer immune response (2017, background): “In an alternative concept known as integrated Wnt pathway, the canonical and noncanonical pathways are combined and multiple inputs at the level of both Wnt-receptor binding and the downstream, intracellular response have been integrated [20].”
- Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “Moreover, Wnts employ receptors of different classes, generating a panoply of combinatorial Wnt signaling critical for correctly shaping tissues during development (van Amerongen and Nusse, 2009), or maintaining tissue architecture in adult life.”
- Building muscle: molecular regulation of myogenesis. (2012, background): “Upon binding to their cellular Frizzled (Fzd) receptors, Wnts function either through canonical activation of the b-catenin/TCF transcriptional complex or through different non-canonical pathways (van Amerongen and Nusse 2009).”