Wnt/beta-catenin signaling in development and disease.

By Hans Clevers. Cell, 2006

5,836 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f3c7f30092b979f39437fd42dae6149713d4d348

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In Molecular Biology

Citations in the corpus

Wnt Signaling Requires the Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes (2010, neutral): “Coinjection of b-Catenin mRNA with HRS-MO or Vps4-EQ showed that MVB formation was required for This new function of b-Catenin in sequestering GSK3 in MVBs occurs upstream of the well-established transcriptional role of b-Catenin and Tcf3 in Wnt signaling (Clevers, 2006).”
Vertebrate Endoderm Development and Organ Formation (2009, background): “Wnts can signal via several distinct intracellular pathways (Clevers 2006, Semenov et al. 2007).”
Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells (2010, positive): “We identified specific mRNAs regulated by Fmrp in stem cell proliferation and differentiation, including glycogen synthase kinase 3b (GSK3ß), a negative regulator of ß-catenin and the canonical Wnt signaling pathway that has been implicated in adult neurogenesis [26,27].”
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin (2020, background): “Gene expression and TF motif activity (inferred from ATAC-seq) of Lef1, a known regulator of the Wnt signaling pathway (Clevers, 2006), activated prior to Hoxc13 (Godwin and Capecchi, 1998), implicating Lef1 as the lineage-priming TF (Merrill et al., 2001).”
G protein-coupled receptors: novel targets for drug discovery in cancer (2010, background): “In the presence of WNTs, β-catenin translocates into the nucleus and transactivates TCF/LEF transcription factors, thereby regulating the expression of genes involved in cell differentiation and proliferatio”
Wnt/β-catenin signaling: components, mechanisms, and diseases (2009, positive): “As a result, mutations in the Wnt pathway are often linked to human birth defects, cancer and other diseases (Clevers, 2006).”
The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “5).454 It is a 19S regulatory particle inhibitor that selectively inhibits the deubiquitinating activity of USP14 and UCHL5 without inhibiting the proteasome activity.455 Additionally, it can also block the degradation of a proteasome-degraded reporter protein, resulting in the accumulation of polyu”