Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

By R. Thimmulappa, Kim H. Mai, S. Srisuma, T. Kensler, Masayuki Yamamoto, Shyam Biswal. Cancer Research, 2002

1,261 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/78d8e65b098fe8b51d91dc33d6cd97d873d9fa5d

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Citations in the corpus

Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals (2008, unknown): “Sulforaphane upregulated the expression of detoxifying enzymes including NQO1, GST and GCL in the small intestine of nrf2 -wild-type mice, while the nrf2 -null mice displayed lower levels of these enzymes [60].”
Physiological effects of broccoli consumption (2008, methodology): “A report of the up- and down-regulation of genes by oral SF treatment (9 lmol/mouse/day for 7 days) in Nrf2(+/+) vs Nrf2(-/-) mice describes the enormity of the number of genes responding to sulforaphane and Nrf2, and thus to many other isothiocyanates also (Thimmulappa et al. 2002).”
Antioxidant defense system is altered by dietary oxidized lipid in first-feeding rainbow trout (Oncorhynchus mykiss) (2014, background): “, 2012) plays a pivotal role in regulating antioxidant defenses especially by regulating the gene expression of GST, GPX and GR (Thimmulappa et al., 2002).”
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. (2012, background): “Some of these genes were listed asNrf2 targets in previousmicroarray analyses conducted in mouse and human (Thimmulappa et al., 2002; MacLeod et al., 2009).”
Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities (2011, unknown): “In addition, this isoflavone may augment glutathione synthesis by increasing the expression of g-glutamylcysteine synthetase (264): the g-glutamylcysteine synthetase gene is a well-studied target of Nrf-nuclear factors (both Nrf1 and Nrf2 have been implicated in its regulation) (353).”
SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. (2003, background): “In vertebrates, Nrf proteins activate transcription of genes encoding the Phase II detoxification enzymes, which constitute the primary cellular defense against oxidative stress (Hayes and McMahon 2001; Thimmulappa et al. 2002).”
Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress (2003, background): “Characterization of the Nrf2 inducible gene set in neurons and glia via microarray analysis The phase II enzyme gene set regulated by Nrf2 is broadening rapidly with the use of microarray technology (Li et al., 2002; Thimmulappa et al., 2002).”
The cytoprotective role of the Keap1–Nrf2 pathway (2011, background): “Nrf2 also regulates the gene expression of other NADPH-generating enzymes, i.e., malic enzyme and phosphogluconate dehydrogenase (Thimmulappa et al. 2002).”