Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

By Andy Y. Shih, Delinda A. Johnson, Gloria Wong, A. Kraft, Lei Jiang, Heidi Erb, Jeffrey A. Johnson, Timothy H. Murphy. Journal of Neuroscience, 2003

776 citations recorded by the source corpus.

Subfields: Biochemistry, Biological Psychiatry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e4cdde901c732ff77321c765bd02bcaee2a70c09

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Citations in the corpus

Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer (2018, background): “Correspondingly, it has been shown that overexpression of NRF2 upregulates the expression of SLC7A11, among other antioxidant target genes, leading to increased GSH biosynthesis [47].”
Astrocytes: biology and pathology (2009, background): “As reviewed in detail elsewhere [226], many studies using transgenic and experimental animal models provide compelling evidence that reactive astrocytes protect CNS cells and tissue by (1) uptake of potentially excitotoxic glutamate [33, 198, 234], (2) protection from oxidative stress via glutathion”
An important role of Nrf2-ARE pathway in the cellular defense mechanism. (2004, background): “, 2003a, 2003b), and overexpression of Nrf2 dramatically increased the resistance of neurons to oxidative cell death (Shih et al., 2003).”
Expression of Nrf2 in Neurodegenerative Diseases (2007, neutral): “Previous studies have shown that astrocytic Nrf2 is sufficient to rescue neurons from oxidative stress (33, 34).”
Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders (2010, positive): “Similar protection was also observed when the small molecule inducers tert -butyl hydroquinone (tBHQ) or sulforaphane were used instead of Nrf2 over-expression (240, 407).”
Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. (2011, background): “In contrast, GSHdepleted astrocytes display a reduced ability to protect neurons against oxidative injury, highlighting the importance of this cooperative mechanism for neuronal defense against oxidative stress (Chen et al., 2001; Shih et al., 2003).”
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex (2004, neutral): “Nrf2 protects against neurotoxic agents (35, 47).”