SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.

By R. Cao, Yi Zhang. Molecules and Cells, 2004

834 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/78731cdb4bf464e836636ad1ae055ff41abfb346

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Citations in the corpus

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation (2014, background): “A series of auxiliary proteins, including SUZ12 and EED, associate with EZH1/2 and modulate targeting, chromatin binding, and catalytic activity (Cao and Zhang, 2004; Ketel et al., 2005; Margueron et al., 2009; Pasini et al., 2004).”
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. (2006, background): “Gene-specific and limited microarray studies have reported that Lys27 methylation tends to occur at punctate sites near promoters of repressed genes (Cao and Zhang, 2004; Kimura et al., 2004; Kirmizis et al., 2004; Koyanagi et al., 2005).”
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. (2008, background): “In addition to the essential role of EED and SUZ12 in PRC2, histone-binding protein RBBP4 (or RbAp48/46) and the zinc finger protein AEBP2 bind to PRC2 and optimize its enzymatic activity in vitro (Cao and Zhang, 2004).”
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. (2005, background): “This category includes the H3-K27 HMTase EZH2 (EED–EZH2 complex) (Cao and Zhang 2004b), and the H4-K20 HMTases pr-SET7 (Fang et al. 2002; Nishioka et al. 2002) and Suv4-20h1,h2 (Schotta et al. 2004).”
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms (2008, background): “omitting RbAp46/48 impeded the compaction mediated through PRC2-Ezh1 but only partially reduced PRC2-Ezh2 HKMT activity (Cao and Zhang, 2004).”
Learning the human chromatin network from all ENCODE ChIP-seq data (2015, background): “The next strongest connections are to SUZ12, which is an essential part of the Polycomb repressive complex 2 (PRC2), and is required for EZH2’s methyltransferase activity [8, 14].”
The landscape of genomic alterations across childhood cancers (2018, neutral): “Together with genes directly affected by breakpoints, in total 70 structural variant-related putative cancer genes were found, many associated with cell cycle or growth (for example, the tumour suppressor PTPRD ) or epigenetic regulators (such as SUZ12 ) 42,43 (Extended Data Fig.”
Transposable elements have rewired the core regulatory network of human embryonic stem cells (2010, background): “For instance, AEBP2 , which encodes a protein found in the PRC2 complex that is known to be important for stem cell self-renewal and differentiatio”
The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation (2007, background): “Loss of Suz12 leads to global loss of H3K27me3 and to destabilization of Ezh2 (9, 32).”
The Polycomb Complex PRC2 and its Mark in Life (2011, background): “It interacts with several PRC2 components to enhance its enzymatic activit”
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. (2004, background): “In agreement with an essential role of Ezh2 in other critical cellular functions (Cao and Zhang 2004a), attempts of reducing the Ezh2 levels 2628 GENES & DEVELOPMENT with RNA interference blocked cell growth (Bracken et al. 2003; data not shown).”
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. (2006, methodology): “Plasmids encoding GST-SET7, GST-SET8, GST-hDOT1L (1–416),and components of the EZH2 complex have been previously described (Cao and Zhang, 2004; Min et al., 2003; Wang et al., 2001a, 2001b).”
The diverse functions of histone lysine methylation (2005, background): “Furthermore, whereas all forms of H3-K27 methylation require EED 79 , SUZ12 seems to be dispensable for the monomethylation of H3-K27 in vivo , although it is indispensable for the enzymatic activity in vitro 80,81 .”
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas (2010, methodology): “Results and Discussion Recombinant PRC2 complexes (16) were prepared with WT and Tyr641 mutant versions of human EZH2 (see Materials and Methods).”
Control of developmental regulators by Polycomb in human embryonic stem cells. (2006, background): “Although the PRCs are known to repress individual HOX genes (van der Lugt et al., 1996; Akasaka et al., 2001; Wang et al., 2002; Cao and Zhang, 2004), it is not clear how these important PcG regulators contribute to early development in vertebrates.”