Control of developmental regulators by Polycomb in human embryonic stem cells.

By Tong Ihn Lee, Richard G. Jenner, Laurie A. Boyer, M. Guenther, S. Levine, Roshan M. Kumar, B. Chevalier, Sarah E. Johnstone, Megan F. Cole, K. Isono and 18 more. Cell, 2006

2,442 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bd96e0e799efa984bd5ea5e9ebbe581345e20268

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Citations in the corpus

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project (2007, background): “In addition to the five ‘activating’ histone marks, we also correlated theTR50 with H3K27me3, a modification associated with polycomb-mediated transcriptional repression 70–74 .”
Aging effects on DNA methylation modules in human brain and blood tissue (2012, methodology): “10 Consensus 111 CRBLM CRBLM brain 47 16-96 Infin 27 k [18] GSE15745”
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms (2008, background): “Previous reports indicated that 95% of Ezh2 targets are within 1 kb of the transcription start site (Lee et al., 2006).”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “A functional role for components of the Polycomb complex during epigenetic remodeling has been suggested by a recent report investigating fusion-mediated reprogramming between ESCs and lymphocytes (Pereira et al. 2010).”
Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition (2014, background): “In cycle 14 embryos, regions both upstream and downstream of the promoters of zygotically expressed genes were enriched for the Polycomb-associated mark H3K27me3 (Figure 5), while the mark was almost completely absent from maternal genes, consistent with the known role of Polycomb group proteins in ”
A Myc rather than core pluripotency module accounts for the shared signatures of embryonic stem and cancer cells (2010, neutral): “between Embryonic Stem and Cancer”
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells (2013, methodology): “Within hours after surgical removal, tumor specimens were enzymatically dissociated into single cells, following the procedures previously reported (Lee et al., 2006a; Son et al., 2009).”
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells (2007, background): “Recent studies have shown that Polycomb proteins are required to silence an important subset of developmental regulator genes in both human and mouse embryonic stem (ES) cells, to ensure that expression occurs only at later stages of ontogeny or upon ES cell differentiatio”
Whole-Genome Analysis of Histone H3 Lysine 27 Trimethylation in Arabidopsis (2007, background): “The Polycomb-group (PcG) protein complexes PhoRC, PRC1, and PRC2 collectively establish and maintain H3K27me3 at ;400 and ;2,000 genes in Drosophila and mammals, respectively [1–4].”
How is pluripotency determined and maintained? (2007, background): “Lee et al. (Lee et al., 2006) performed ChIP-on-Chip analysis for Suz12, Eed and H3K27me3, and revealed that Suz12- and Eed-binding sites significantly overlap with each other and with H3K27me3 marks on the highly evolutionarily-conserved regions of transcriptionally silent genes, including Gata4 an”
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. (2008, background): “In mouse and human ES cells, a large number of developmental genes are regulated by Polycomb group (PcG) proteins, which are responsible for establishing H3K27 trimethylation (Boyer et al. 2006; Lee et al. 2006).”