The diverse functions of histone lysine methylation

By Cyrus Martin, Yi Zhang. Nature reviews. Molecular cell biology, 2005

2,142 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1a93ac98fad1f9aade57a627bca514f38d3ebf17

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In Molecular Biology

1. Ryuji Hamamoto
2. Yusuke Nakamura
3. Yi Zhang
4. Yang Shi
5. G. Toyokawa
6. Hyun-soo Cho
7. S. Hayami
8. N. Dohmae

Citations in the corpus

• The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. (2007, positive): “It has also been implicated in heterochromatin formation, X inactivation, genomic imprinting, and silencing of homeotic genes, demonstrating an important role for histone methylation in multiple biological processes (Martin and Zhang, 2005).”
• Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (2006, background): “Histone methylation has been implicated in multiple biological processes including heterochromatin formation, X-inactivation, genomic imprinting, and silencing of homeotic genes (Kouzarides, 2002; Lachner and Jenuwein, 2002; Margueron et al., 2005; Martin and Zhang, 2005).”
• Histone demethylation by a family of JmjC domain-containing proteins (2006, background): “One such modification, methylation, occurs on both lysine and arginine residues and participates in a diverse range of biological processes including heterochromatin formation, X-chromosome inactivation and transcriptional regulation 2–4 .”
• Histone acetyltransferase complexes: one size doesn't fit all (2007, background): “Since then, much progress has been made in understanding the role of histone methylation in heterochromatin formation, transcriptional activation and transcriptional repression (reviewed in Ref”
• EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. (2008, background): “It has been speculated that EZH2 may have independent functions that do not involve H3K27 methylation (Martin and Zhang, 2005; Pasini et al., 2007; Rajasekhar and Begemann, 2007; Schwartz and Pirrotta, 2007).”
• How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers (2007, background): “Genome-wide assessments show that these methylation states at particular lysine residues are enriched in certain regions of chromatin, implying that these marks have specialized and distinct biological function”
• Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. (2008, neutral): “These histone methylations include the trimethylation of histone H3 at Lys 9 (H3K9me3) and of histone H4 at Lys 20 (H4K20me3), which define constitutive heterochromatin, and H3K27me3, which defines facultative heterochromatin (Martin and Zhang 2005; Sarma and Reinberg 2005).”