JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.

By K. Yamane, Charalambos Toumazou, Y. Tsukada, H. Erdjument‐Bromage, Paul Tempst, J. Wong, Yi Zhang. Cell, 2006

844 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/17a2442dc014b9a1f6a87bf05a45e4f5097b07b2

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Citations in the corpus

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. (2007, neutral): “Although its function is unclear, a C2HC4 zinc finger has been shown to be important for JHDM2A demethylase activity (Yamane et al., 2006).”
Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex. (2007, background): “Conversely, knockdown of JMJD2C inhibits androgeninduced removal of trimethyl H3K9 and transcriptional activation by the AR (67).”
Active DNA Demethylation Mediated by DNA Glycosylases (2009, positive): “Oxidative demethylation of methylated histone H3 lysine 9 or lysine 36 by JmjC ( Jumonji C) domain-containing proteins has been demonstrated (96, 107).”
The JmjC domain‐containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene (2012, background): “KDM3A (lysine-specific demethylase 3A; also known as JMJD1A) mainly demethylates mono- and dimethyl-H3K9, with cofactors Fe2þ and aKG, resulting in H3K9 demethylation and transcriptional activation.(6) KDM3A is preferentially expressed in the testis and plays an essential role in spermatogenesis.”
Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact (2012, background): “These enzymes, as well as the H3K9 di-demethylases KDM3A-KDM3C (also known as JMJD1AJMJD1C), were identified by assaying chromatography fractions for the ability to release formaldehyde from methylated histones (Tsukada et al., 2006; Yamane et al., 2006).”
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. (2008, background): “Thus, LSD1, JMJD1A, JMJD1C, and JMJD2C have been involved in AR-mediated transcription (Fig. 4; Metzger et al. 2005; Yamane et al. 2006; Wissmann et al. 2007; Wolf et al. 2007).”
ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs (2011, positive): “To further evaluate the alternative possibility that the actions of KDM4C that critically dictated growth control gene expression might reside in its histone H3K9 demethylase activity, rather than actions on Pc2K191me2, we took advantage of the previous observations that different H3K9 demethylases ”