Molecular basis of long-term plasticity underlying addiction

By E. Nestler. Nature Reviews Neuroscience, 2001

1,060 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Genetics, Physiology

View Paper: https://www.semanticscholar.org/paper/78551fd5af1e170b940fccf2d4b28f3c88adca6f

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Citations in the corpus

Molecular mechanisms of memory reconsolidation (2007, background): “One potential mechanism for such aberrant reconsolidation mechanisms could be long-lasting drug-induced adaptations, including long-lasting upregulation of activity of cell signalling pathways such as cAMP, and downstream transcription factors such as CREB and ΔFos”
The addicted human brain: insights from imaging studies. (2003, background): “Low level of brain dopamine D(2) receptors in”
The incentive sensitization theory of addiction: some current issues (2008, background): “changes that cause the transition to addiction from casual or recreational drug use, and the features that make particular individuals especially susceptible to the transition (Robinson & Berridge 1993; Nestler 2001; Hyman et al. 2006; Kalivas & O’Brien 2008).”
Addiction and the brain antireward system. (2008, background): “As dependence and withdrawal develop, brain antireward systems such as CRF, norepinephrine, and dynorphin are recruited (Figures 2 and 3), producing aversive or stress-like states (Aston-Jones et al. 1999, Koob 2003a, Nestler 2001).”
Brain circuitry and the reinstatement of cocaine-seeking behavior (2003, background): “This is consistent with the clearly established changes in gene expression and cellular physiology in the nucleus accumbens produced by repeated cocaine administration (White and Kalivas 1998; Nestler 2001).”
Drug Addiction as a Pathology of Staged Neuroplasticity (2008, background): “In summary, activation of the D1, CREB, and deltaFosB signaling cascade is clearly necessary for driving the neuroplasticity underlying both biological motivated learning and developing drug-seeking behaviors (Nestler, 2001; Hyman et al, 2006).”
Structural plasticity associated with exposure to drugs of abuse. (2004, neutral): “Importantly, these intracellular signaling pathways have been implicated in mediating the actions of psychostimulant drugs, behavioral and neurochemical sensitization, various forms of experience-dependent plasticity, as well as structural plasticity (Nestler, 2001; Chao and Nestler, 2004).”
Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, background): “As with other forms of memory, it is hypothesized that changes in gene expression or protein translation play an important role in memory storage (Berke & Hyman 2000, Nestler 2001).”
The GDNF family: Signalling, biological functions and therapeutic value (2002, background): “The abuse of psychostimulant drugs induces behavioural sensitization, a form of dopamine-mediated neuronal plasticit”
Psychomotor Stimulant Addiction: A Neural Systems Perspective (2002, background): “Transitional mechanisms related to corticostriatal plasticity As reviewed elsewhere, the striatum might be a critical site at which cellular and molecular adaptations to chronically administered drugs affect learning (Hyman and Malenka, 2001; Nestler, 2001).”
Addiction and the brain: The neurobiology of compulsion and its persistence (2001, background): “Recent reviews have addressed the complex molecular changes induced by addictive drugs in relevant neural circuit”
The reinstatement model of drug relapse: history, methodology and major findings (2003, background): “In fact, some of the neuroadaptive changes in response to drugs (Wolf 1998; Flores and Stewart 2000; Nestler 2001) involve molecular substrates known to be involved in memory formation and retrieval.”
The neural basis of addiction: a pathology of motivation and choice. (2005, background): “The prototype signaling cascade in this regard is D1 dopamine receptor stimulation resulting in the activation of cAMP-dependent protein kinase (PKA), PKA-induced phosphorylation of the transcriptional regulator cAMP response element binding protein (CREB), and the induction of immediate early gene ”
Transcriptional and Epigenetic Mechanisms of Addiction (2011, background): “We, and others, have long proposed that changes in the transcriptional potential of genes — through the actions of transcription factors, chromatin modifications and non-coding RNAs — contribute substantially to many of the neuroadaptations that result from chronic exposure to drugs of abus”