Structural plasticity associated with exposure to drugs of abuse.

By Terry E. Robinson, B. Kolb. Neuropharmacology, 2004

1,122 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/4440d3737b888db9b9b0e2f0bad2605f72d2af07

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Is there a common molecular pathway for addiction? (2005, background): “Chronic exposure to cocaine, amphetamine or nicotine causes long-lasting increases in dendritic arborization and in the density of dendritic spines of these neuron”
Transcriptional and Epigenetic Mechanisms of Addiction (2011, background): “, ΔFOSB mediates the structural plasticity that is induced in NAc by cocain”
Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, background): “R.M. is on the Scientific Advisory Boards of Merck & Co., Inc. and Renovis, Inc.”
Synaptic plasticity and addiction (2007, result): “These findings are consistent not only with the behavioural effects of the LTD-blocking peptides but also with reports that chronic in vivo administration of psychostimulants increase the density of dendritic spines on NAc medium spiny neuron”
Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. (2008, background): “Animal studies have elegantly demonstrated that cognitive deficits on tests of inhibitory control can be induced by relatively short-term courses of drug administration (Jentsch et al., 2002; Ricaurte et al., 2000; Robinson and Kolb, 2004).”
Liking, Wanting and the Incentive-Sensitization Theory of Addiction (2016, background): “…also changes the physical structure of mesolimbic neurons, such as altering the shape and number of tiny spines on dendrites of neurons in nucleus accumbens, which act as their ‘receiving antennae’ for incoming signals (T. E. Robinson & Kolb, 2004; Singer et al., 2009; Steketee & Kalivas, 2011).”
The Addicted Synapse: Mechanisms of Synaptic and Structural Plasticity in Nucleus Accumbens (2010, background): “For example, morphine and cocaine alter the density of dendritic spines on medium spiny neurons (MSNs) in nucleus accumbens (NAc), a key brain reward region, to a greater extent in animals self-administering the drug, compared to animals given drug by the investigator, suggesting that volition may b”
Habits, rituals, and the evaluative brain. (2008, background): “A particular advantage of studies on addiction is that they can be used to uncover cellular and molecular mechanisms that promote transition to the addicted state (Hyman et al. 2006, Robinson & Kolb 2004, Self 2004).”
The glutamate homeostasis hypothesis of addiction (2009, background): “Subsequently, drug-induced dendritic changes were shown to be widespread in the striatum, although specific effects in subcompartments have been associated with differences in drug exposure and environmental condition”
Imaging dopamine's role in drug abuse and addiction. (2009, positive): “Consistent with this line of thought, there is mounting evidence that exposure to stimulants, nicotine, or opiates produces persistent adaptive changes in the structure of dendrites and dendritic spines on cells in key areas of the brain with roles in motivation, reward, judgment, and the inhibitory”
Cortico-Basal Ganglia Reward Network: Microcircuitry (2009, positive): “…a potential substrate for enabling local plasticity of glutamate transmission based on synaptic experience (Flores et al, 2005; Day et al, 2006; Surmeier et al, 2007) or chronic exposure to psychostimulants that enhance DA levels (Robinson and Kolb, 2004; Wolf et al, 2004; Lee et al, 2006).”
Model-Based and Model-Free Pavlovian Reward Learning: Revaluation, Revision and Revelation (2014, background): “…sensitize dopamine-related circuits in susceptible individuals in ways that enhance neural responses to learned reward cues (Leyton & Vezina, 2012; T. E. Robinson & Berridge, 2008; T. E. Robinson & Kolb, 2004; Thomas, Kalivas, & Shaham, 2008; Vezina & Leyton, 2009; Wolf & Ferrario, 2010).”
Drug Addiction as a Pathology of Staged Neuroplasticity (2008, background): “Primary among these is the well-established changes in dendritic spine density seen in the NA and prefrontal cortical areas after repeated administration of addictive drugs (Robinson and Kolb, 2004).”