Addiction and the brain antireward system.

By G. Koob, M. Le Moal. Annual Review of Psychology, 2008

1,404 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/85a6f10e6545f2d70d1d6c4515ba287e14c10b55

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In Behavioral Neuroscience

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Citations in the corpus

Pro v Con Reviews: Is Food Addictive? (2012, background): “The involvement of the habenula as an antireward hub within emotional networks is consistent with prior theoretical models of addiction that postulated that sensitized stress reactivity and negative mood (mediated through enhanced sensitivity of the amygdala and increased signalling although the cor”
The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. (2009, methodology): “In two more rats, BDA was injected into the LHb along with CTB injections into the VTA; anterogradely labeled fibers apposed a substantial number of retrogradely labeled RMTg neurons (Figure 2J), though we did not assess whether these neurons exhibited stimulus-induced Fos.”
Reward Processing by the Opioid System in the Brain (2009, neutral): “Reinforcing properties of drugs are considered critical for the initiation of drug use but are insufficient to explain the maintenance of compulsive drug intake (201).”
Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity (2014, background): “AD subjects also presented with psychological symptoms, including depression, anxiety, and alcohol craving, which contribute to the negative reinforcement process, a major mechanism involved in the persistence of alcohol dependence (38) that is related to a higher probability of relapse after detoxi”
Reward Mechanisms in Obesity: New Insights and Future Directions (2011, background): “…and in interoceptive processing (insular cortex) have been heavily implicated in drug addiction (Everitt et al., 2008; Fineberg et al., 2010; Koob and Volkow, 2010; Naqvi and Bechara, 2009), yet little is known of their precise role in compulsive eating and obesity, e.g., (Nair et al.,…”
Clinical psychology of Internet addiction: a review of its conceptualization, prevalence, neuronal processes, and implications for treatment (2015, neutral): “85,86 In periods of abstinence, the lack of dopamine release in the brain leads to withdrawal symptoms that can only be alleviated via reinstatement of the addictive behavior.”