The reinstatement model of drug relapse: history, methodology and major findings

By Y. Shaham, U. Shalev, Lin Lu, H. de Wit, J. Stewart. Psychopharmacology, 2003

1,660 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Clinical Psychology, Toxicology

View Paper: https://www.semanticscholar.org/paper/a9d4b75aa88dacffe443ab298e03b9253dbd95aa

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In Cellular and Molecular Neuroscience

In Clinical Psychology

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Citations in the corpus

The debate over dopamine’s role in reward: the case for incentive salience (2007, background): “Just as a small taste of food UCS can prime appetite to eat more, or a small jolt of free brain stimulation or drug reward can prime self-administration of the same reward, conditioned priming by a CS for many of these rewards acts to elicit motivation to obtain the UCS reward (Berridge 2004; Bindra”
The role of impulsive behavior in drug abuse (2008, background): “However, some aspects of this procedure deviate from the human condition, and its substitutability as a model for relapse in humans has been extensively discussed elsewhere (e.g., Epstein et al. 2006; Katz and Higgins 2003; Shaham and Miczek 2003; Shaham et al. 2003).”
REVIEW: Behavioural assessment of drug reinforcement and addictive features in rodents: an overview (2006, methodology): “For a better overview of the present state of this question, we recommend reading the reviews by Epstein & Preston (2003) and Shaham et al. (2003).”
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion (2005, background): “Studies of the cued reinstatement of extinguished responding for cocaine ( Box 2 ) have been reviewed extensively elsewher”
A role for brain stress systems in addiction. (2008, positive): “Animal models of craving (preoccupation/anticipation stage) involve reinstatement of drug seeking following extinction from the drugs themselves, by cues linked to the drug, and from exposure to stressors (Shaham et al., 2003) (Table 1).”
Neurocircuitry of Addiction (2009, background): “In contrast, stress-induced reinstatement of drug-related responding in animal models appears to depend on the activation of both CRF and norepinephrine in elements of the extended amygdala (both the CeA and BNST; for reviews, see Shaham et al, 2003; Shalev et al, 2002).”
Extinction circuits for fear and addiction overlap in prefrontal cortex. (2009, background): “Following extinction, cocaine seeking can be reinstated by presenting a discrete cue that was paired with cocaine delivery, low doses of cocaine itself, or stress (De Wit and Stewart 1981; Shaham et al. 2003; Epstein et al. 2006).”
Addiction and the brain antireward system. (2008, background): “BNST, bed nucleus of the stria terminalis; CRF, corticotropin-releasing factor; HPA, hypothalamic-pituitary-adrenal axis; NE, norepinephrine.”
Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure (2006, methodology): “CONSTRUCT VALIDITY of the reinstatement model, referring primarily to the literature on heroin, alcohol, and cocaine, as these are the drugs that have been most extensively tested in this model (Bossert et al. 2005; Shaham et al. 2003; Shalev et al. 2002).”
Neurobiological mechanisms for opponent motivational processes in addiction (2008, background): “Animal models of the preoccupation/anticipation (‘craving’) stage involve reinstatement of drug seeking following extinction elicited by the drugs themselves, by cues linked to the drug and by exposure to stressors (Weiss et al. 2001; Shaham et al. 2003) and measures of protracted abstinence (table ”
Motivation concepts in behavioral neuroscience. (2004, background): “For example, although drug withdrawal occurs as a b-process after heroin, it is surprisingly often not the reason why addicts keep taking drugs [126,145].”
Harnessing neuroplasticity for clinical applications (2011, neutral): “A noteworthy exception regarding the paucity of valid animal models in psychiatry is found in the addictive disorders, where a rich array of models is available for study (Shaham et al., 2003; Guo et al., 2006; Ninkovic and Bally-Cuif, 2006).”
Sex Differences in Animal Models: Focus on Addiction (2016, background): “…the preoccupation/anticipation stage of drug addiction, involve the reinstatement of drug-seeking behavior after extinction training and subsequent exposure to the drugs themselves, cues/contexts that are paired with drug self-administration, or stressors (Self, 1998; Shaham et al., 2003).”