Addiction and the brain: The neurobiology of compulsion and its persistence

By S. Hyman, R. Malenka. Nature Reviews Neuroscience, 2001

1,349 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/3670b51b49b3f819caa70fd9d0617715f46ba979

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Kent C. Berridge
2. Nora D. Volkow
3. R. Malenka
4. E. Nestler
5. S. Hyman
6. Terry E. Robinson
7. Barry J. Everitt
8. G. Koob

In Cognitive Neuroscience

1. Kent C. Berridge
2. B. Casey
3. Nora D. Volkow
4. E. Nestler
5. S. Hyman
6. R. Malenka
7. Rebecca M. Jones
8. Adriana Galvan

In Pharmacology

1. Kent C. Berridge
2. B. Kolb
3. Terry E. Robinson
4. E. Nestler
5. S. Hyman
6. P. R. Montague
7. J. Cohen
8. A. Citri

Citations in the corpus

• The adolescent brain. (2008, neutral): “…2000; Pecina, Cagniard, Berridge, Aldridge, & Zhuang, 2003; Schultz, 2006) and adult imaging studies (e.g., Knutson, Adams, Fong, & Hommer, 2001; O,Doherty, Kringelbach, Rolls, Hornak, Andrews, 2001; Zald et al., 2004) and in studies of addiction (Hyman & Malenka, 2001; Volkow & Li, 2004).”
• The Neuroscience of Natural Rewards: Relevance to Addictive Drugs (2002, background): “Addictive drugs induce long-term neuroadaptations at the structural, cellular, molecular, and genomic levels (Hyman and Malenka, 2001), but how does such plasticity relate to natural reward and motivation? An exciting synthesis is emerging from studies of glutamate–DA-mediated plasticity and its tra”
• Motivation concepts in behavioral neuroscience. (2004, background): “The theory does not deny that drug pleasure, withdrawal, or habits are all reasons people sometimes take drugs [77,88,124], but suggests that something else, sensitized ‘wanting’, may better explain compulsive long-lasting addiction and relapse.”
• Orbitofrontal cortex and its contribution to decision-making. (2007, background): “For example, drugs of abuse are thought to sensitize the nucleus accumbens, which misdirects behavior towards drug acquisition (Everitt & Robbins 2005, Hyman & Malenka 2001, Robinson & Berridge 2003).”
• Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “Excitatory synaptic transmission in these structures is critical for mediating several forms of longlasting, drug-induced behavioral plasticity (Everitt and Wolf, 2002; Hyman and Malenka, 2001).”
• Computational roles for dopamine in behavioural control (2004, methodology): “A new way to conceptualize the process of addiction is in the terms described abov”
• The Adolescent Brain (2008, background): “…regions implicated in reward-related learning and behavior in animal (Hikosaka & Watanabe 2000; Pecina et al. 2003; Schultz 2006) and adult imaging studies (e.g., Knutson et al. 2001; O’Doherty et al. 2001; Zald et al. 2004) and in studies of addiction (Hyman & Malenka 2001; Volkow & Li 2004).”
• Earlier Development of the Accumbens Relative to Orbitofrontal Cortex Might Underlie Risk-Taking Behavior in Adolescents (2006, methodology): “, 2004), risk-taking (Kuhnen and Knutson, 2005), and addiction (Hyman and Malenka, 2001; Volkow et al., 2004), but less is known about the development of these systems.”