Drug Addiction as a Pathology of Staged Neuroplasticity

By Peter W. Kalivas, C. O'Brien. Neuropsychopharmacology, 2008

734 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1a1b1c3c3b3e7befda62c380787bf2d3f3db7a4f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Nora D. Volkow
2. G. Koob
3. R. Malenka
4. S. Lammel
5. C. Lüscher
6. Jochen Roeper
7. D. Ion
8. Xiaoping P. Hu

In Molecular Biology

1. Nora D. Volkow
2. G. Koob
3. Jochen Roeper
4. Xiaoping P. Hu
5. S. Lammel
6. Xiaobing Jiang
7. H. Zhang
8. Ning Ma

Citations in the corpus

• Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli (2011, positive): “…may correspond to a transition from limbic and prefrontal cortical control over goal-directed behavior to dorsostriatal control as drug intake becomes compulsive (Haber et al., 2000; Kalivas and Volkow, 2005; Everitt and Robbins, 2005; Everitt et al., 2008; Hyman et al., 2006; Ikemoto, 2007).”
• Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling (2011, background): “Drug-evoked synaptic plasticity in various parts of the mesocorticolimbic systemmay constitute the underlying cellular correlate, confirming the hypothesis that ‘‘staged neuroplasticity’’ underlies the disease (Kalivas and O’Brien, 2008).”
• Addiction related alteration in resting-state brain connectivity (2010, positive): “The neurobiological foundation of these models is mainly based on the results of functional activation studies in human addicts and the observation that exposure to addictive drugs produces persistent structural and functional changes on cells within this network (Garavan et al., 2000; Goldstein et ”
• Neurocircuitry of Addiction (2009, background): “Consistent with the results of altered glutamate neurotransmission in cocaine-sensitized rats, microdialysis and microinjection studies have shown that following chronic cocaine, decreased basal release of glutamate occurs but sensitized synaptic glutamate release during reinstatement of extinguishe”