CpG islands – ‘A rough guide’

By Robert S. Illingworth, A. Bird. FEBS Letters, 2009

911 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ba6b72455c9df95bc62bd0922d9203425d4f29c5

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Citations in the corpus

Prenatal environmental exposures, epigenetics, and disease (2011, neutral): “In these regions, cytosine methylation serves a regulatory function [14].”
Climate Change Impacts on Seagrass Meadows and Macroalgal Forests: An Integrative Perspective on Acclimation and Adaptation Potential (2018, background): “So-called CpG islands represent clusters of CG sites in gene promoter regions, and are commonly associated with gene expression regulation (Bossdorf et al., 2008; Illingworth and Bird, 2009; Zhang and Jeltsch, 2010).”
CpG islands and the regulation of transcription. (2011, neutral): “Recent related reviews include Illingworth and Bird (2009), Mohn and Schubeler (2009), and Blackledge and Klose (2011).”
Rethinking how DNA Methylation Patterns are Maintained (2009, background): “In somatic cells, most CpG islands remain unmethylated independently of the state of gene expression, with the exception of genes on the inactive X chromosome, germ cell-specific genes and a minority of other gene”
R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters (2012, positive): “Genome-level studies confirm that the large majority (82%–94%, depending on the study) of promoter CGIs are unmethylated in normal tissues (Illingworth and Bird, 2009).”
DNA methylation and healthy human aging (2015, background): “…Sarah J. Goodman1,2 and Michael S. Kobor1,2,3 1Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, 2Department of Medical Genetics, 3Human Early Learning Partnership, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada”
Child health, developmental plasticity, and epigenetic programming. (2011, background): “In mammals, nearly all m5C is found at sites where cytosines are followed by guanines (CpG dinucleotides) (57).”
DNA-binding factors shape the mouse methylome at distal regulatory regions (2011, background): “Importantly these regions do not resemble CpG islands, which are a different class of well-described hypomethylated regions in the genom”