Epigenetic regulation of neurogenesis in the adult mammalian brain

By Jiaqi Sun, Jiawei Sun, Guo-li Ming, Hongjun Song. 2011

121 citations recorded by the source corpus.

Epigenetic regulation represents a fundamental mechanism to maintain cell‐type‐specific gene expression during development and serves as an essential mediator to interface the extrinsic environment and the intrinsic genetic programme. Adult neurogenesis occurs in discrete regions of the adult mammalian brain and is known to be tightly regulated by various physiological, pathological and pharmacological stimuli. Emerging evidence suggests that various epigenetic mechanisms play important roles in fine‐tuning and coordinating gene expression during adult neurogenesis. Here we review recent progress in our understanding of various epigenetic mechanisms, including DNA methylation, histone modifications and non‐coding RNAs, as well as cross‐talk among these mechanisms, in regulating different aspects of adult mammalian neurogenesis.

Subfields: Developmental Neuroscience, Genetics, Molecular Biology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Many molecular players and signaling pathways have been identified, including niche factors/receptors, cytoplasmic factors, transcriptional factors, and epigenetic regulators (reviewed by Ma et al., 2010; Mu et al., 2010; Ninkovic and Gö tz, 2007; Sun et al., 2011).”