Dynamic DNA methylation programs persistent adverse effects of early-life stress

By C. Murgatroyd, A. Patchev, Yonghe Wu, V. Micale, Yvonne Bockmühl, D. Fischer, F. Holsboer, Carsten T. Wotjak, O. Almeida, D. Spengler. Nature Neuroscience, 2009

1,193 citations recorded by the source corpus.

Subfields: Molecular Biology, Pediatrics, Perinatology and Child Health, Social Psychology

View Paper: https://www.semanticscholar.org/paper/371cbbf061a88ad931dc5ec172f5d49eafb1c9e5

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Citations in the corpus

Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation. (2016, background): “Enduring behavioral responses to stress and epigenetic alterations in adult offspring have been demonstrated to be mediated by changes in gametes (10–13), in utero effects (14), variations in early postnatal care (15,16), and/or other early life experiences (17) that are influenced by parental expos”
Maternal adversity and ecological stressors in natural populations: the role of stress axis programming in individuals, with implications for populations and communities (2013, background): “A number of other groups have also found evidence of epigenetic regulation in the brain by altered parental care or stress-related early adversity (e.g. Murgatroyd et al. 2009; Roth et al. 2009).”
Linking Molecules to Mood: New Insight Into the Biology of Depression (2010, neutral): “Early life stress applied to mice produces hypomethylation of the arginine vasopressin (AVP) gene in the hypothalamic paraventricular nucleus, resulting in hypersecretion of AVP, pathologically enhanced serum corticosterone level and increased depression-like behavior (84).”
The Lifelong Effects of Early Childhood Adversity and Toxic Stress (2012, background): “The precise biological mechanisms that explain these findings remain to be elucidated, but epigenetic modifications of DNA appear likely to play a role.(31,33,34) Early postnatal experiences with adversity are also thought to affect future reactivity to stress, perhaps by altering the developing neu”
11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. (2013, background): “Indeed, the key HPA axis drivers, corticotropin releasing hormone (CRH) and arginine vasopressin (AVP), and feedback receptor, glucocorticoid receptor (GR), show altered expression in models of programming and the promoters of all three encoding genes show persisting changes in methylation in respon”
Borderline Personality Disorder (2016, neutral): “In fact, early adversity in general has been found to be associated with persistent changes of stress responsivity, possibly via epigenetic mechanisms [36].”
Effects of the social environment and stress on glucocorticoid receptor gene methylation: a systematic review (2014, neutral): “Moreover, prolonged periods of maternal separation alter the methylation state of the promoter for the avp gene, increasing hypothalamic AVP synthesis and HPA responses to stress (98).”
“The Biological Effects of Childhood Trauma” (2014, neutral): “tion alter the methylation state of the promoter for the AVP gene in the pup, increasing hypothalamic vasopressin AVP synthesis and LHPA responses to stress, along with memory deficits and learned helplessness behaviors.(108)”
Epigenetic modifications and human disease (2010, background): “and in the Avp enhancer for mice subjected to early-life stres”
Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics. (2012, neutral): “…as well as demethylation of specific regulatory sites in key genes for stress processing including the gene encoding of the glucocorticoid receptor as well as the gene encoding of the neuropeptide arginine vasopressin (AVP) (McGowan et al., 2009; Murgatroyd et al., 2009; Weaver et al., 2004).”
Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates (2012, positive): “For example, stress has been shown to alter gene expression patterns through specific changes in DNA methylation (Murgatroyd et al., 2009).”
Aging effects on DNA methylation modules in human brain and blood tissue (2012, background): “For example, early-life-induced programming that relies on DNA methylation appears to be at a considerable risk to become disrupted during aging [12,13].”