Aberrant epigenetic landscape in cancer: how cellular identity goes awry.

By M. Berdasco, Manel Esteller. Developmental Cell, 2010

595 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d1388cbe25354217378bc488c596c897425b16df

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Holger Heyn
2. W. Grady
3. Bing Ren
4. V. Lao
5. Manel Esteller
6. Alfonso Valencia
7. Jun Wang
8. Zhike Lu

Citations in the corpus

• EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. (2015, background): “Changes to these modifications are often found in diseases such as cancer and are best studied for those diseases (89, 90).”
• Hallmarks of cancer: the next generation. (2011, unknown): “clues that specific shifts in chromatin configuration occur during the acquisition of certain hallmark capabilities (Berdasco and Esteller, 2010).”
• Epigenetics and Colorectal Cancer (2011, background): “Other important roles for DNA methylation include silencing of repetitive centromeric sequences as well as transposons and other endoparasitic sequences; these latter functions seem to be important for maintaining genomic stability ( Figure 1 )”
• CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing (2011, unknown): “This may be especially relevant in pathological conditions, such as cancer, where widespread changes in DNA methylation, altered CTCF binding, and aberrant alternative pre-mRNA splicing have been reporte”
• Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification (2011, background): “Resource”
• Distinct DNA methylomes of newborns and centenarians (2012, background): “Considering that epigenetic regulation has emerged as a critical driver of cell fate and survival that targets many pathways (3, 4), that epigenetic drift can occur even in genetically identical humans (5, 6), and that DNA methylation patterns are disrupted in a wide range of common human diseases (”
• Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome (2011, background): “The disruption of the DNA methylation profile is a major hallmark of human cancer.(1,2) Among the aberrant DNA methylation signatures of transformed cells there are two key events in tumorigenesis: the promoter CpG island hypermethylationassociated inactivation of tumor suppressor genes and the glob”