Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells.

By G. Pan, Shulan Tian, Jeff Nie, Chuhu Yang, Victor Ruotti, Hairong Wei, Gudrun A. Jonsdottir, Ron M. Stewart, James A. Thomson. Cell Stem Cell, 2007

731 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7556b9ed82077eae8724966dfd6b102354551f2b

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Citations in the corpus

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains (2008, background): “domains may reflect multiple, distinct regulatory entities [16–18].”
Histone methylation by PRC2 is inhibited by active chromatin marks. (2011, background): “, 2009), a mechanism implicated in creating and maintaining the extended H3K27me3 domains at target genes in vivo (Bernstein et al., 2006; Pan et al., 2007; Papp and Müller, 2006; Schwartz et al., 2006).”
Distinct Epigenomic Landscapes of Pluripotent and Lineage-committed Human Cells (2010, background): “H3K4me3, H3K4me2, H3K4me1, H3K9ac, H3K9me3, H3K27ac, H3K27me3, H3K36me3, H3K18ac and H4K5ac were tested.”
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. (2009, background): “…are consistent with recent observations that H3K4me3 associates extensively with proximal promoters in human T cells, as well as human and murine embryonic stem cells (Barski et al., 2007; Fouse et al., 2008; Guenther et al., 2007; Mikkelsen et al., 2007; Pan et al., 2007; Zhao et al., 2007).”
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (2010, methodology): “Histone methylation status in sperm versus somatic cells To relate genomic localization to chromatin regulation during development, we compared ChIP patterns in sperm to those generated in human embryonic stem cells (hESCs) and primary fibroblast”
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008, background): “…neuron are highly enriched for genes involved in neuronal development, ion transport, and neurotransmitter regulation (Group 1 in Figures 4B and 4C and Table S1), in line with previous findings that many neuronal genes are targeted by Polycomb in ESCs (Boyer et al., 2006; Pan et al., 2007).”
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation (2009, background): “Studies using ESCs suggest that bivalent modifications maintain the activation or silencing potential of critical differentiation genes (Azuara et al., 2006; Bernstein et al., 2006).”
The Polycomb Complex PRC2 and its Mark in Life (2011, background): “H3K27me3 enrichment seems to be centred around the transcription start site of promoters, but with a lower intensity at the start site itsel”
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. (2010, positive): “These bivalent domains are also found in hematopoietic cells, neural progenitors, and fibroblasts, indicating they are not restricted to cultured embryonic stem cells (Mikkelsen et al., 2007; Oguro et al., 2010; Pan et al., 2007; Roh et al., 2006).”
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. (2007, background): “These histone modification statuses are characteristic of hES cells (Pan et al., 2007).”
An extended transcriptional network for pluripotency of embryonic stem cells. (2008, background): “In parallel, other work has suggested that histone modification signatures, specifically histone 3 lysine 4 and histone 3 lysine 27 trimethylation (H3K4me3 and H3K27me3, respectively), are important in controlling gene regulation in ES cells (Bernstein et al., 2006; Boyer et al., 2006; Lee et al., 2”
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts (2009, neutral): “To further elucidate the functional significance of these R-DMRs, we looked at their overlap with bivalent domains, which mark developmental genes in embryonic stem (ES) cell”
Control of Embryonic Stem Cell State (2011, background): “…during differentiation (Azuara et al., 2006; Bernstein et al., 2006; Boyer et al., 2006; Bracken et al., 2006; Endoh et al., 2008; Landeira et al., 2010; Lee et al., 2006; Li et al., 2010; Pan et al., 2007; Pasini et al., 2010; Peng et al., 2009; Shen et al., 2009; van der Stoop et al., 2008).”