Rhythmic histone acetylation underlies transcription in the mammalian circadian clock

By J. Etchegaray, Choogon Lee, P. Wade, Steven M. Reppert. Nature, 2003

702 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/74dcb7c98e0f4b539bb0f691c63474a8626e9aa6

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Citations in the corpus

Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions (2006, neutral): “The circadian binding of CLOCK and BMAL1 to Dbp E-box elements in vivo and in vitro does not conform to the proposal that these factors remain bound to DNA throughout the day and serve as a chromatin platform for the repressors CRY and PE”
Mammalian circadian biology: elucidating genome-wide levels of temporal organization. (2004, background): “The REV-ERBα protein inhibits transcription from the Bmal1 gene, and perhaps also from the Clock and Cry1 genes, by binding retinoic acid-related orphan receptor response elements (ROREs) in their promoters (4, 59, 73, 142, 154, 200).”
Molecular components of the mammalian circadian clock. (2006, background): “The chromatin remodeling necessary for this cyclic transcriptional activity is achieved by a combination of clock-specific and ubiquitous histonemodifying proteins and can be observed in the rhythmic acetylation/deacetylation of histones (H3 and H4) at multiple clock target genes (Etchegaray et al. ”
Molecular components of the Mammalian circadian clock. (2013, background): “The chromatin remodeling necessary for this cyclic transcriptional activity is achieved by a combination of clock-specific and ubiquitous histonemodifying proteins and can be observed in the rhythmic acetylation/deacetylation of histones (H3 and H4) at multiple clock target genes (Etchegaray et al. ”
A clockwork web: circadian timing in brain and periphery, in health and disease (2003, background): “Although Clock/Bmal1 complexes bind to target DNA E-BOX SEQUENCES at all phases of the cycle, activation of gene expression is associated with circadian-gated chromatin remodelling by histone acetylatio”
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. (2008, background): “... components is observed around 42 hr. Therefore, SIRT1 might also regulate the expression of circadian output genes expressed with a different phase, possibly through activation of coactivators and transcription factors such as PGC1a, FOXO, or LXR (Dali-Youcef et al., 2007; Li et al., 2007) or th”
A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. (2004, background): “…reduced overall activity that couldform in the liver is determined by a combination of activilimit our detection of deficits in circadian locomotor ac-ties from both E box and ROR elements surrounding tivity, we compared a number of locomotor activity pa-the Cry1 TSS (Etchegaray et al., 2003).”
The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “Recent work has shown that circadian transcription of CLOCK–BMAL1 target genes is accompanied by circadian changes in histone H3 acetylation and chromatin remodellin”
Post-translational modifications regulate the ticking of the circadian clock (2007, neutral): “Depending on the specific target gene, CLOCK and BMAL1 either remain bound to the promoters throughout the circadian cycle (as for the Per genes”
Molecular Architecture of the Mammalian Circadian Clock (2013, background): “Transcriptional initiation likely requires removal of CRY1 from CLOCK:BMAL1 in favor of the histone acetyltransferase coactivators p300 and CBP [63, 77], which begins at CT4 and continues for the next four hours with a simultaneous increase in histone acetylation [39].”