The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease
By J. Takahashi, Heekyung Hong, C. H. Ko, Erin L. McDearmon. Nature reviews genetics, 2008
1,585 citations recorded by the source corpus.
Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The genetic basis of circadian rhythms is well studied in model organisms and, more recently, studies of the genetic basis of circadian disorders has confirmed the conservation of key players in circadian biology from invertebrates to humans. In addition, important advances have been made in understanding how these molecules influence physiological functions in tissues throughout the body. Together, these studies set the scene for applying our knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.
Subfields: Endocrine and Autonomic Systems, Experimental and Cognitive Psychology, Physiology
View Paper: https://www.semanticscholar.org/paper/df3480483389ca77b599eaa4b9cef88bd10b54dc
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In Endocrine and Autonomic Systems
- J. Takahashi
- Steve A. Kay
- David K. Welsh
- U. Albrecht
- Satchidananda Panda
- J. Lipton
- T. Scammell
- E. Arrigoni
In Experimental and Cognitive Psychology
In Physiology
Citations in the corpus
- Suprachiasmatic Nucleus: Cell Autonomy and Network Properties (2010, background): “In recent years, there has been a growing recognition of the importance of clock genes and circadian regulation for health; circadian clock genes have been directly implicated not only in sleep disorders but also in diabetes, cancer, and bipolar disorder (4).”
- A circadian clock in macrophages controls inflammatory immune responses (2009, background): “Recent years have witnessed an enormous progress in our understanding of the molecular basis of the circadian clock and its importance for health and disease (26).”
- Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease (2010, background): “For example, polymorphisms in clock genes ( Box 3 ) have been associated with bipolar disorder and alcohol addictio”
- Sleep: a health imperative. (2012, neutral): “33 A number of genes are essential for the generation of circadian rhythms in mammals 31 ; because of the interaction of circadian processes and sleep, it is not surprising that some clock genes (i.e., genes that affect both the persistence and period of circadian rhythms) appear to have effects on…”