Post-translational modifications regulate the ticking of the circadian clock

By M. Gallego, D. Virshup. Nature reviews. Molecular cell biology, 2007

861 citations recorded by the source corpus.

Subfields: Aging, Cognitive Neuroscience, Endocrine and Autonomic Systems

View Paper: https://www.semanticscholar.org/paper/da5defab8f0db10fe724bed61a4a783b6124ce39

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. J. Takahashi
2. U. Albrecht
3. C. Dibner
4. A. Jetten
5. U. Schibler

In Cognitive Neuroscience

1. J. Takahashi
2. U. Albrecht
3. A. Jetten

In Endocrine and Autonomic Systems

1. J. Takahashi
2. U. Albrecht
3. C. H. Ko
4. C. Dibner
5. A. Jetten
6. U. Schibler
7. Heekyung Hong
8. Erin L. McDearmon

Citations in the corpus

• Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer (2008, background): “, together with the increasing links between nightshift work and the incidences of breast and endometrial cancers, suggests that this F-box protein might be involved in processes contributing to cance”
• Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “…casein kinases and other kinases and acetylation, play a critical role in regulating protein-protein interactions, the nuclear localization, transcriptional activity, and turnover of clock proteins [Eide et al., 2005; Gallego and Virshup, 2007; Ko and Takahashi, 2006; Ripperger and Schibler, 2001].”
• Design principles of biochemical oscillators (2008, background): “We consider a protein (for example, PER in the circadian control system of fruit flie”
• The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “Recent work shows that post-translational modification and degradation of circadian clock proteins are crucial steps for determining circadian periodicity of the cloc”
• The mammalian circadian timing system: organization and coordination of central and peripheral clocks. (2010, result): “Work on mammalian and insect oscillators resulted in similar conclusions for metazoan systems (221, 222), which may explain why absolute cellular concentrations of known clock components do not appear to play preponderant roles in keeping the clocks ticking (see above).”
• SIRT1 regulates circadian clock gene expression through PER2 deacetylation. (2008, neutral): “Other posttranslational modifications such as phosphorylation, sumoylation, histone acetylation, and methylation have already been shown to play a key role in circadian gene expression (Gallego and Virshup, 2007).”