Molecular Architecture of the Mammalian Circadian Clock

By C. Partch, C. Green, J. Takahashi. Trends in Cell Biology, 2013

1,330 citations recorded by the source corpus.

Circadian clocks coordinate physiology and behavior with the 24-hour solar day to provide temporal homeostasis with the external environment. The molecular clocks that drive these intrinsic rhythmic changes are based on interlocked transcription/translation feedback loops that integrate with diverse environmental and metabolic stimuli to generate internal 24-hour timing. In this review we highlight recent advances in our understanding of the core molecular clock and how it utilizes diverse transcriptional and post-transcriptional mechanisms to impart temporal control onto mammalian physiology. Understanding the way in which biological rhythms are generated throughout the body may provide avenues for temporally-directed therapeutics to improve health and prevent disease.

Subfields: Endocrine and Autonomic Systems, Physiology, Plant Science

View Paper: https://www.semanticscholar.org/paper/ca9aa3640b2cde1d18c610ac130dda2d6727b2f5