Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions

By J. Ripperger, U. Schibler. Nature Genetics, 2006

602 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/2436c53c9a80cf121c62d29bfe59c0c2c8da22e6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. J. Takahashi
2. Paolo Sassone-Corsi
3. C. H. Ko
4. Ethan D. Buhr
5. J. Hirayama
6. M. Doi
7. C. Dibner
8. U. Schibler

In Molecular Biology

1. J. Takahashi
2. Paolo Sassone-Corsi
3. R. Mostoslavsky
4. L. Guarente
5. J. Hirayama
6. M. Doi
7. C. H. Ko
8. Saurabh Sahar

In Plant Science

1. J. Takahashi
2. C. H. Ko
3. Paolo Sassone-Corsi
4. Ethan D. Buhr
5. J. Hirayama
6. M. Doi
7. U. Schibler
8. C. Dibner

Citations in the corpus

• System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock (2007, background): “Since BMAL1 and CLOCK are metabolically more stable than CRY and PER proteins, their abundance varies only slightly throughout the day [16,18, 19 ].”
• Circadian regulator CLOCK is a histone acetyltransferase. (2006, positive): “Paradoxical to the central role played by CLOCK in the rhythmic transcription of the clock-controlled genes, expression of CLOCK is described to be nearly constitutive (Lee et al., 2001; Ripperger and Schibler, 2006).”
• Molecular components of the Mammalian circadian clock. (2013, background): “The chromatin remodeling necessary for this cyclic transcriptional activity is achieved by a combination of clock-specific and ubiquitous histonemodifying proteins and can be observed in the rhythmic acetylation/deacetylation of histones (H3 and H4) at multiple clock target genes (Etchegaray et al. ”
• The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control (2008, positive): “The PCR primers for mDbp mRNA, mPer2 mRNA, mCry1 mRNA, 18S rRNA, Dbp UP, Dbp E-box, Dbp 30R, and mSIRT1 mRNA were described (Ripperger and Schibler, 2006; Rodgers et al., 2005; Yamamoto et al., 2004).”
• SIRT1 regulates circadian clock gene expression through PER2 deacetylation. (2008, positive): “, 2007) or through the circadian deacetylation of histones in nucleosomes associated with clock-controlled genes (Belden et al., 2007; Curtis et al., 2004; Etchegaray et al., 2003; Naruse et al., 2004; Ripperger and Schibler, 2006).”
• Molecular components of the mammalian circadian clock. (2006, background): “The chromatin remodeling necessary for this cyclic transcriptional activity is achieved by a combination of clock-specific and ubiquitous histonemodifying proteins and can be observed in the rhythmic acetylation/deacetylation of histones (H3 and H4) at multiple clock target genes (Etchegaray et al. ”
• Reprogramming of the Circadian Clock by Nutritional Challenge (2013, positive): “We next explored whether CLOCK:BMAL1 chromatin recruitment might contribute to the altered pattern of Dbp expression by chromatin immunoprecipitation (Ripperger and Schibler, 2006).”