Growth, Adipose, Brain, and Skin Alterations Resulting from Targeted Disruption of the Mouse Peroxisome Proliferator-Activated Receptor β(δ)

By J. Peters, S. Lee, Wen Li, J. Ward, O. Gavrilova, Carrie Everett, M. Reitman, L. Hudson, F. Gonzalez. Molecular and Cellular Biology, 2000

695 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/739c959410d3120549e099786ff5b6ecaba8d8f5

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Citations in the corpus

The mechanisms of action of PPARs. (2002, background): “It is therefore noteworthy that PPARδ null mice were found to have diminished myelination levels of the corpus callosum (182), an area normally rich in PPARδexpressing oligodendrocytes (see above).”
Integration of metabolism and inflammation by lipid-activated nuclear receptors (2008, background): “Consistent with this concept, Ppard −/− mice have placental defects that result in increased embryonic lethality and myelination defects, decreased amounts of adipose tissue, and altered wound healing and responses to skin inflammatio”
Towards Fish Lipid Nutrigenomics: Current State and Prospects for Fin-Fish Aquaculture (2008, background): “PPARβ-deficient mice show reduced adipose stores (Peters et al., 2000), and treatment with synthetic ligands has demonstrated that PPARβ directly controls lipid utilization through up-regulation of genes involved in β-oxidation and energy uncoupling in various tissues (Dressel et al., 2003;…”
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (2010, background): “However, the use of these mice or those in which PPAR (cid:6) is genetically disrupted (Peters et al., 2000) has not been reported in investigations of endocannabinoids and their analogs.”
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors (2006, background): “Important functions have been assigned to this isotype in the skin, gut, placenta, skeletal muscle, adipose tissue, and brain (Braissant et al., 1996; Bastie et al., 1999; Peters et al., 2000; Michalik et al., 2001; Barak et al., 2002).”
Emerging roles of PPARS in inflammation and immunity (2002, background): “PPARβ/δ deficiency was reported originally to negatively affect growth, adipose-tissue stores and myelination of the corpus callosu”
Peroxisome-proliferator-activated receptors and cancers: complex stories (2004, background): “In mouse keratinocytes, Pparβ/δ inhibits proliferation and promotes cell survival and migratio”
Regulation of energy metabolism by long-chain fatty acids. (2014, background): “Other reported abnormalities of PPARd KO mice include impaired myelination [126] and wound healing of skin [128].”