The mechanisms of action of PPARs.

By J. Berger, D. Moller. Annual Review of Medicine, 2002

2,641 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/13d798e37ef78ffd97ab2eab150df8ce96953396

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Citations in the corpus

The role of Peroxisome Proliferator-Activated Receptors (PPAR) in immune responses (2020, background): “PPARα and PPARδ are highly expressed in oxidative tissues and regulate genes involved in substrate delivery, substrate oxidation, and oxidative phosphorylation (OXPHOS) [3,9].”
Omega-3 polyunsaturated fatty acids and cardiovascular diseases. (2009, background): “Although fatty acids are classically observed as an energy substrate, they are also endogenous ligands for PPARs and regulate the expression of genes encoding key proteins controlling fatty acid uptake and metabolism and the formation of very-low-density lipoproteins carrying triglycerides in the li”
Integration of metabolism and inflammation by lipid-activated nuclear receptors (2008, background): “) The three PPARs have different tissue distributions and seem to have distinct but overlapping biological function”
Myocardial substrate metabolism in the normal and failing heart. (2005, background): “The effective insulin-sensitizing agents, the thiazolidinediones, are PPAR ligands and act to sequester fatty acids in adipocytes, lower circulating fatty acids, and triglycerides and therefore reduce the exposure of the myocardium to fatty acids (25).”
Activation of PPARα and PPARγ by Environmental Phthalate Monoesters (2003, background): “By contrast, two other PPAR forms help regulate diverse physiological processes in several other tissues, with PPAR essential for adipogenesis and PPAR playing a role in development (Berger and Moller, 2002).”
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. (2007, background): “C/EBP is required for adipogenesis as well as gene expressions for lipid metabolism and inflammation (2, 59).”
Molecular cues to implantation. (2004, background): “PPAR is well known as a key metabolic regulator participating in obesity control, diabetes, atherosclerosis, and other processes (262).”
Enzymes of triacylglycerol synthesis and their regulation. (2004, background): “PPARa is a transcription factor that is also activated by fibrates and by fatty acids, particularly in fasted animals [234].”
Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. (2004, background): “The preferred natural ligands of PPAR are PUFAs, including LA, -LNA, AA, and EPA (80, 81).”
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α (2003, background): “, we considered that it may interact with a member of this nuclear receptor famil”