Peroxisome-proliferator-activated receptors and cancers: complex stories

By L. Michalik, B. Desvergne, W. Wahli. Nature Reviews. Cancer, 2004

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Mammalian lipoxygenases and their biological relevance (2014, background): “scription factors, have also been described for various LOX products [123,124].”
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors (2006, background): “Finally, growing evidence implicates PPAR , as well as the two other isotypes, in tumor development in different tissues, although whether PPAR activation promotes or limits this process remains under debate and may depend on specific conditions (Michalik et al., 2004; Peters et al., 2005; Burdick e”
Obesity and Cancer: The Role of Dysfunctional Adipose Tissue (2009, background): “PPAR-γ, which is mainly expressed in adipose tissue, is an important regulator of adipocyte differentiation and function, as well as cell proliferation and survival (148, 149).”
Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications – a review (2014, background): “Its high expression in the large intestine has been implicated in the development of colon cancer [11,47].”