Integration of metabolism and inflammation by lipid-activated nuclear receptors

By S. Bensinger, P. Tontonoz. Nature, 2008

830 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/f10637ea3c99acf1a13100e39130bfc4199dadf8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. K. Bornfeldt
2. Douglas R. Green
3. Hongbo Chi
4. I. Tabas
5. C. V. Dang
6. Erika L. Pearce
7. J. Wells
8. Olivier Julien

In Molecular Biology

1. K. Bornfeldt
2. L. Hue
3. R. Ross
4. Douglas R. Green
5. G. FitzGerald
6. Hongbo Chi
7. I. Tabas
8. H. Taegtmeyer

In Surgery

1. K. Bornfeldt
2. L. Hue
3. I. Tabas
4. H. Taegtmeyer
5. C. Stanton
6. C. V. Dang
7. R. Kaufman
8. J. Malhotra

Citations in the corpus

• Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review (2014, background): “fatty acids, prostanoids) [19,26,144–151] and synthetic [13,151–153] ligands of the receptor have been reviewed in numerous previous articles and therefore will not be discussed here.”
• Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids (2012, background): “The peroxisome proliferator-activated receptor (PPAR) family is composed of three proteins: PPARα, PPARβ/δ, and PPARγ, and, although they each have different tissue distributions, their biological functions overlap [57].”
• HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells (2011, background): “In support of this notion, proper regulation of glucose and sterol metabolism is required for the development of adaptive immune responses (Bensinger and Tontonoz, 2008; Bensinger et al., 2008; Cham et al., 2008).”
• Insulin Resistance, Hyperglycemia, and Atherosclerosis (2011, positive): “However, systemically administered LXR agonists promote steatosis, and currently available thiazolidinediones have been associated with heart failure and possibly bladder cancer (Bensinger and Tontonoz, 2008).”
• The Randle cycle revisited: a new head for an old hat. (2009, background): “Although beyond the scope of our review, it should be added that PPARs also control several inflammatory processes (12), which is relevant to pathological conditions such as atherosclerosis and type 2 diabetes.”