Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

By Anneli Seppälä‐Lindroos, S. Vehkavaara, A. Häkkinen, Takashi Goto, J. Westerbacka, Anssi Sovijärvi, Juha Halavaara, Hannele Yki-Järvinen. Journal of Clinical Endocrinology and Metabolism, 2002

1,133 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/70e6aa0228a9491d8b21cbc94cd305ed332d8782

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In Endocrinology, Diabetes and Metabolism

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Citations in the corpus

Diabetic dyslipidaemia: from basic research to clinical practice* (2003, background): “Notably there is a close positive correlation between fasting plasma triglycerides and liver fat quantitated by using proton spectroscopy in humans [72].”
Overproduction of large VLDL particles is driven by increased liver fat content in man (2006, background): “Insulin resistance is associated with atherogenic dyslipidaemia characterised by high levels of triglyceride (TG)rich lipoproteins and their cholesteryl ester-rich remnant particles, low levels of HDL-cholesterol, and small dense LDL [1].”
Waist Circumference and Cardiometabolic Risk (2007, background): “In fact, increased intrahepatic fat is associated with dyslipidemia and hepatic insulin resistance (23), and increased intramyocellular fat is associated with skeletal muscle insulin resistance (24).”
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome (2010, background): “Intrahepatic lipid accumulation is, in fact, independent of BMI”
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB (2005, methodology): “We isolated IKK complexes from mouse liver lysates using anti-IKK-γ antibodies (PharMingen) coupled to protein A-Sepharose, and conducted in vitro kinase assays at 30 °C by adding [γ-32P]ATP and 2 μg of GST-IκBα (1-54)12.”
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. (2009, background): “We propose that the increased hepatic lipid resulting from fructose-induced DNL leads to hepatic insulin resistance (49, 50), possibly by increasing levels of diacylglycerol (49).”
A position statement on NAFLD/NASH based on the EASL 2009 special conference. (2010, background): “Even in healthy, normal weight individuals, liver fat is associated with several features of IR, independent of BMI and intra-abdominal obesity [80].”
Disordered lipid metabolism and the pathogenesis of insulin resistance. (2007, neutral): “Nonalcoholic steatohepatitis is also increasingly recognized as a component of the insulin resistance or metabolic syndrome (64, 76, 101).”
Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. (2005, background): “The accuracy and safety of (1)H MRS make it an ideal methodology to assess and monitor changes in HTGC in response to various therapeutic interventions (29, 39, 40, 43) and to examine the natural history of the disorder.”